State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Changchun, 130022, P. R. China.
School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, P. R. China.
Angew Chem Int Ed Engl. 2022 Nov 2;61(44):e202209484. doi: 10.1002/anie.202209484. Epub 2022 Sep 29.
Owing to the high depth of tissue penetration, non-invasiveness, and controllability, ultrasound (US)-mediated sonodynamic therapy (SDT) has shown broad application prospects for tumor treatment. However, the electron-hole separation inefficiency of sonosensitizers and the tumor hypoxia remain two major challenges limiting the effect of SDT. Here, ultrafine photoetched bismuth vanadate (BiVO ) nanorods modified with DSPE-PEG (PEBVO@PEG NRs) were fabricated to achieve in situ self-supply of oxygen (O ) and reactive oxygen species (ROS) for hypoxic tumor therapy. The photoetching approach could enhance the charge separation by inducing enriched oxygen vacancies on the surface of BiVO , thereby improving the generation efficiency of ROS and O . The PEBVO@PEG overcome the main obstacles of traditional sonosensitizers in the SDT process and show promising sonodynamic therapeutic effects, thus providing new strategies for improving the performance of sonosensitizer and hypoxic tumor elimination.
由于具有组织穿透深度高、非侵入性和可控性等优点，超声（US）介导的声动力学疗法（SDT）在肿瘤治疗方面显示出广阔的应用前景。然而，声敏剂的电子-空穴分离效率低和肿瘤缺氧仍然是限制 SDT 效果的两个主要挑战。在这里，制备了经过超细光蚀刻的二硒化铋钒（BiVO ）纳米棒修饰的 DSPE-PEG（PEBVO@PEG NRs），以实现缺氧肿瘤治疗中氧气（O ）和活性氧（ROS）的原位自供给。光蚀刻方法可以通过在 BiVO 表面诱导富氧空位来增强电荷分离，从而提高 ROS 和 O 的生成效率。PEBVO@PEG 克服了传统声敏剂在 SDT 过程中的主要障碍，并表现出有前途的声动力学治疗效果，从而为提高声敏剂性能和消除缺氧肿瘤提供了新策略。
