Friberg T R, Lace J, Rosenstock J, Raskin P
Can J Ophthalmol. 1987 Jun;22(4):226-9.
Microaneurysms were counted separately in a masked manner on stereo colour fundus photographs and on stereo fluorescein angiograms of 100 patients with unselected forms of diabetic retinopathy. Serial studies obtained 6 months apart were available for most patients, and a total of 315 separate photographic studies were evaluated. In addition, 118 photographic studies of 38 young patients with type I diabetes mellitus were evaluated. About twice as many microaneurysms were detected on the fluorescein angiograms as on the colour photographs for both groups of patients (p less than 0.05). Fluorescein angiography showed microaneurysms in 57% of the eyes in the second group photographed for the first time that had no detectable microaneurysms on colour photography. The use of fluorescein angiography is recommended in diabetic patients when detection of subtle microvascular abnormalities is deemed essential.
对100例未经挑选的糖尿病视网膜病变患者的立体彩色眼底照片和立体荧光素血管造影照片进行了盲法单独计数微动脉瘤。大多数患者可获得间隔6个月的系列研究，共评估了315项单独的摄影研究。此外，还评估了38例I型糖尿病年轻患者的118项摄影研究。两组患者荧光素血管造影检测到的微动脉瘤数量约为彩色照片的两倍（p<0.05）。荧光素血管造影显示，在首次拍摄的第二组眼睛中，57%的眼睛在彩色摄影中未检测到微动脉瘤，但在荧光素血管造影中显示有微动脉瘤。当认为检测细微的微血管异常至关重要时，建议糖尿病患者使用荧光素血管造影。
