感染 COVID-19 的母亲或亲属所生新生儿中 SARS-CoV-2 感染的流行情况。
Prevalence of SARS-CoV-2 infection in neonates born to mothers or relatives with COVID-19.
机构信息
Department of Medical Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Department of Virology, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
出版信息
BMC Infect Dis. 2022 Sep 8;22(1):730. doi: 10.1186/s12879-022-07688-6.
BACKGROUND
In December 2019, in Wuhan, China, coronavirus disease 2019 (COVID-19) was emerged due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). It seems that children and neonates, similar to adult and elderly individuals, are at risk of SARS-CoV-2 infection. However, adequate data are not available about neonates infected with SARS-CoV-2.
METHODS
This study evaluated the presence of SARS-CoV-2 infection in neonates born to mothers or relatives with COVID-19. This cross-sectional study was performed on 25,044 consecutive Iranian participants in Tehran, Iran, from January 2020 to August 2020. Viral ribonucleic acid (RNA) was extracted from 500 µl of the oropharyngeal and nasopharyngeal specimens of the participants. The genomic RNA of SARS-CoV-2 was detected by real-time polymerase chain reaction (PCR) assay.
RESULTS
Out of all participants, 98 (0.40%) cases were neonates born to mothers or relatives with SARS-CoV-2 infection. Therefore, the current study was performed on these neonates. Out of 98 studied neonates, 6 (6.1%) cases had positive PCR results for SARS-CoV-2 infection. Moreover, among 98 studied neonates' mothers, 25 (25.5%) cases had positive PCR results for SARS-CoV-2 infection.
CONCLUSION
The findings of this study demonstrated that the rate of COVID-19 in neonates born to mothers or relatives with SARS-CoV-2 infection in the Iranian population is about 6.1%.
背景
2019 年 12 月，在中国武汉，由于严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的出现，出现了 2019 年冠状病毒病（COVID-19）。儿童和新生儿似乎与成人和老年人一样，有感染 SARS-CoV-2 的风险。然而，关于感染 SARS-CoV-2 的新生儿，目前还没有足够的数据。
方法
本研究评估了 COVID-19 母亲或亲属所生的新生儿中 SARS-CoV-2 感染的存在情况。本横断面研究于 2020 年 1 月至 2020 年 8 月在伊朗德黑兰对 25044 例连续伊朗参与者进行。从参与者的咽和鼻咽标本中提取 500μl 病毒核糖核酸（RNA）。通过实时聚合酶链反应（PCR）检测 SARS-CoV-2 的基因组 RNA。
结果
在所有参与者中，有 98 例（0.40%）是 COVID-19 母亲或亲属所生的新生儿。因此，本研究仅针对这些新生儿进行。在 98 例研究的新生儿中，有 6 例（6.1%）的 SARS-CoV-2 感染 PCR 结果为阳性。此外，在 98 例研究的新生儿母亲中，有 25 例（25.5%）的 SARS-CoV-2 感染 PCR 结果为阳性。
结论
本研究的结果表明，在伊朗人群中，COVID-19 母亲或亲属所生的新生儿中 COVID-19 的发病率约为 6.1%。
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