Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Arthritis Res Ther. 2022 Sep 8;24(1):217. doi: 10.1186/s13075-022-02905-8.
To investigate whether the associations between cartilage defects and cartilage volumes with changes in knee symptoms were mediated by osteophytes.
Data from the Vitamin D Effects on Osteoarthritis (VIDEO) study were analyzed as a cohort. The Western Ontario and McMaster Universities Osteoarthritis Index was used to assess knee symptoms at baseline and follow-up. Osteophytes, cartilage defects, and cartilage volumes were measured using magnetic resonance imaging at baseline. Associations between cartilage morphology and changes in knee symptoms were assessed using linear regression models, and mediation analysis was used to test whether these associations were mediated by osteophytes.
A total of 334 participants (aged 50 to 79 years) with symptomatic knee osteoarthritis were included in the analysis. Cartilage defects were significantly associated with change in total knee pain, change in weight-bearing pain, and change in non-weight-bearing pain after adjustment for age, sex, body mass index, and intervention. Cartilage volume was significantly associated with change in weight-bearing pain and change in physical dysfunction after adjustment. Lateral tibiofemoral and patellar osteophyte mediated the associations of cartilage defects with change in total knee pain (49-55%) and change in weight-bearing pain (61-62%) and the association of cartilage volume with change in weight-bearing pain (27-30%) and dysfunction (24-25%). Both cartilage defects and cartilage volume had no direct effects on change in knee symptoms.
The significant associations between cartilage morphology and changes in knee symptoms were indirect and were partly mediated by osteophytes.
研究软骨缺损和软骨体积与膝关节症状变化的相关性是否受骨赘的影响。
对维生素 D 对骨关节炎（VIDEO）研究的数据进行了分析。采用西安大略和麦克马斯特大学骨关节炎指数评估基线和随访时的膝关节症状。在基线时使用磁共振成像测量骨赘、软骨缺损和软骨体积。采用线性回归模型评估软骨形态与膝关节症状变化之间的相关性，并采用中介分析来检验这些相关性是否受骨赘的影响。
共纳入 334 名（年龄 50-79 岁）有症状性膝骨关节炎的参与者。调整年龄、性别、体重指数和干预因素后，软骨缺损与总膝关节疼痛、负重疼痛和非负重疼痛的变化显著相关。软骨体积与负重疼痛和身体功能障碍的变化显著相关。外侧胫股和髌股骨赘中介了软骨缺损与总膝关节疼痛变化（49-55%）和负重疼痛变化（61-62%）以及软骨体积与负重疼痛变化（27-30%）和功能障碍变化（24-25%）的相关性。软骨缺损和软骨体积对膝关节症状的变化均无直接影响。
软骨形态与膝关节症状变化之间的显著相关性是间接的，部分受骨赘的影响。
