Department of Nephrology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Institute of Nephrology, China; School of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, China.
Ultrasound in Cardiac Electrophysiology and Biomechanics Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.
Biomed Pharmacother. 2022 Sep;153:113438. doi: 10.1016/j.biopha.2022.113438. Epub 2022 Aug 1.
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease and is an enormous burden on both patients and society. There is an urgent need for effective alternative therapeutic strategies for the treatment of DN, as medical treatment is currently limited. The anti-inflammatory, antioxidative, anti-apoptotic, and anti-fibrosis properties of curcumin, a polyphenol curcuminoid, have been demonstrated in research on diabetic nephropathy. The clinical and preclinical trials and mechanisms by which curcumin affects DN have been discussed in this review. A deeper understanding of the pharmacological effects of curcumin on diabetic nephropathy may provide new therapies to improve the development and occurrence of diabetic nephropathy.
糖尿病肾病（DN）是终末期肾病的主要原因，给患者和社会都带来了巨大的负担。目前，医学治疗手段有限，因此迫切需要有效的治疗 DN 的替代治疗策略。姜黄素是一种多酚类姜黄素，其具有抗炎、抗氧化、抗细胞凋亡和抗纤维化作用，在糖尿病肾病的研究中得到了证实。本综述讨论了姜黄素对 DN 的临床和临床前研究和作用机制。深入了解姜黄素对糖尿病肾病的药理作用可能为改善糖尿病肾病的发生和发展提供新的治疗方法。
