Li Hao, Dai Wenni, Xiao Li, Sun Lin, He Liyu
Department of Nephrology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha 410011, China.
Pharmaceutics. 2023 Aug 17;15(8):2150. doi: 10.3390/pharmaceutics15082150.
Kidney disease has become a serious public health problem throughout the world, and its treatment and management constitute a huge global economic burden. Currently, the main clinical treatments are not sufficient to cure kidney diseases. During its development, nanotechnology has shown unprecedented potential for application to kidney diseases. However, nanotechnology has disadvantages such as high cost and poor bioavailability. In contrast, biopolymers are not only widely available but also highly bioavailable. Therefore, biopolymer-based nanosystems offer new promising solutions for the treatment of kidney diseases. This paper reviews the biopolymer-based nanosystems that have been used for renal diseases and describes strategies for the specific, targeted delivery of drugs to the kidney as well as the physicochemical properties of the nanoparticles that affect the targeting success.
肾脏疾病已成为全球范围内严重的公共卫生问题，其治疗和管理构成了巨大的全球经济负担。目前，主要的临床治疗方法尚不足以治愈肾脏疾病。在其发展过程中，纳米技术已显示出在肾脏疾病应用方面前所未有的潜力。然而，纳米技术存在成本高和生物利用度差等缺点。相比之下，生物聚合物不仅来源广泛，而且具有很高的生物利用度。因此，基于生物聚合物的纳米系统为肾脏疾病的治疗提供了新的有前景的解决方案。本文综述了已用于肾脏疾病的基于生物聚合物的纳米系统，并描述了将药物特异性、靶向递送至肾脏的策略以及影响靶向成功的纳米颗粒的物理化学性质。
