Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Biomed Pharmacother. 2022 Sep;153:113449. doi: 10.1016/j.biopha.2022.113449. Epub 2022 Jul 23.
Cell-to-cell communication networks have indispensable roles in coordinating various biological processes in cancer cells or altering metabolism activity in both cancer and non-cancer cells. Exosomes, migrasomes, ectosomes, apoptotic bodies, and exomeres belonging to the heterogeneous world of extracellular vesicles (EVs), which have gained significant attention in recent years due to their principal role in cell-to-cell communication, including Extracellular Circulating miRNAs (ECmiRNAs) as a rich cargo content. ECmiRNAs can be taken up by target cells to mediate heterotypic cell-interactions and facilitate recipient repression in neighboring cells. The complex of ECmiRNAs with EVs, proteins, and lipoproteins structures such as TLR, AGO protein complex, HDL, and LDL can be more effective as mediators between cancer cells. The mechanism of multidrug resistance and angiogenesis in cancer cells may be altered during special signaling of EVs-ECmiRNAs during cell-to-cell communication. Also, those complexes may serve as novel biomarkers in cancer prognostication.
细胞间通讯网络在协调癌细胞中的各种生物过程或改变癌细胞和非癌细胞中的代谢活性方面发挥着不可或缺的作用。外泌体、迁移体、ectosomes、凋亡小体和 exomeres 属于细胞外囊泡 (EVs) 的异质世界，由于它们在细胞间通讯中的主要作用，近年来引起了广泛关注，包括作为丰富 cargo 内容的细胞外循环 miRNA (ECmiRNAs)。ECmiRNAs 可以被靶细胞摄取，以介导异型细胞相互作用，并促进邻近细胞中的受体抑制。ECmiRNAs 与 EVs、蛋白质和脂蛋白结构（如 TLR、AGO 蛋白复合物、HDL 和 LDL）的复合物可以作为癌细胞之间的更有效的介质。在细胞间通讯过程中，EV-ECmiRNAs 的特殊信号可能会改变癌细胞中的多药耐药和血管生成机制。此外，这些复合物可以作为癌症预后的新型生物标志物。
