醇类在催化有氧氧化条件下的 Passerini 三组分反应。
Passerini three-component reaction of alcohols under catalytic aerobic oxidative conditions.
机构信息
Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France.
出版信息
Org Lett. 2010 Apr 2;12(7):1432-5. doi: 10.1021/ol100012y.
PMID:20218637
Abstract
Alcohols instead of aldehydes were used in the Passerini three-component reaction under catalytic aerobic conditions. Mixing alcohols, isocyanides, and carboxylic acids in toluene in the presence of a catalytic amount of cupric chloride, NaNO(2), and TEMPO afforded, under an oxygen atmosphere, the P-3CR adducts in good yields.
摘要
在催化有氧条件下的 Passerini 三组分反应中使用醇代替醛。在氧气气氛下，将醇、异氰化物和羧酸在催化量的氯化亚铜、亚硝酸钠和 TEMPO 的存在下混合在甲苯中，以良好的收率得到 P-3CR 加合物。
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