Division of Biochemistry and Structural Biology, Lund University, 22 100 Lund, Sweden.
Laboratory of Pathophysiological and Nutritional Biochemistry, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Int J Mol Sci. 2022 Aug 25;23(17):9615. doi: 10.3390/ijms23179615.
Aquaporins (AQPs) are a family of transmembrane water channels expressed in all living organisms. AQPs facilitate osmotically driven water flux across biological membranes and, in some cases, the movement of small molecules (such as glycerol, urea, CO, NH, HO). Protein-protein interactions play essential roles in protein regulation and function. This review provides a comprehensive overview of the current knowledge of the AQP interactomes and addresses the molecular basis and functional significance of these protein-protein interactions in health and diseases. Targeting AQP interactomes may offer new therapeutic avenues as targeting individual AQPs remains challenging despite intense efforts.
水通道蛋白（AQP）是一类在所有生物中表达的跨膜水分子通道。AQP 促进生物膜两侧渗透压驱动的水分子流动，在某些情况下，还促进小分子（如甘油、尿素、CO、NH、HO）的运动。蛋白-蛋白相互作用在蛋白质调节和功能中发挥着重要作用。本综述全面概述了目前对 AQP 相互作用组的认识，并探讨了这些蛋白-蛋白相互作用在健康和疾病中的分子基础和功能意义。尽管针对单个 AQP 进行靶向治疗极具挑战性，但针对 AQP 相互作用组进行靶向治疗可能提供新的治疗途径。
