Département de Chimie et Biochimie, Université de Moncton, Moncton, NB E1A 3E9, Canada.
Atlantic Cancer Research Institute, Université de Moncton, Moncton, NB E1C 8X3, Canada.
Int J Mol Sci. 2022 Sep 3;23(17):10095. doi: 10.3390/ijms231710095.
PAX5, a member of the Paired Box (PAX) transcription factor family, is an essential factor for B-lineage identity during lymphoid differentiation. Mechanistically, PAX5 controls gene expression profiles, which are pivotal to cellular processes such as viability, proliferation, and differentiation. Given its crucial function in B-cell development, aberrant expression also correlates with hallmark cancer processes leading to hematological and other types of cancer lesions. Despite the well-established association of in the development, maintenance, and progression of cancer disease, the use of as a cancer biomarker or therapeutic target has yet to be implemented. This may be partly due to the assortment of expressed products, which layers the complexity of their function and role in various regulatory networks and biological processes. In this review, we provide an overview of the reported data describing products, their regulation, and function in cellular processes, cellular biology, and neoplasm.
PAX5 是配对盒 (PAX) 转录因子家族的成员，是淋巴分化过程中 B 细胞谱系身份的必需因子。从机制上讲，PAX5 控制着对细胞过程至关重要的基因表达谱，例如存活、增殖和分化。鉴于其在 B 细胞发育中的关键功能，异常表达也与导致血液学和其他类型癌症病变的标志性癌症过程相关。尽管在癌症疾病的发展、维持和进展中已经确定了 的关联，但尚未将其作为癌症生物标志物或治疗靶点使用。这可能部分归因于 表达产物的种类繁多，这增加了它们在各种调节网络和生物过程中的功能和作用的复杂性。在这篇综述中，我们提供了对描述 产物的报告数据的概述，以及它们在细胞过程、细胞生物学和肿瘤中的调节和功能。
