Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Department of Medical Instruments Engineering, Al-Maarif University College, Al Anbar, 31001, Iraq.
Cell Biochem Biophys. 2024 Sep;82(3):1979-1991. doi: 10.1007/s12013-024-01404-8. Epub 2024 Aug 13.
Circular RNAs (circRNAs) are single-stranded RNAs that have received much attention in recent years. CircRNAs lack a 5' head and a 3' poly-A tail. The structure of this type of RNAs make them resistant to digestion by exonucleases. CircRNAs are expressed in different cells and have various functions. The function of circRNAs is done by sponging miRNAs, changing gene expression, and protein production. The expression of circRNAs changes in different types of cancers, which causes changes in cell growth, proliferation, differentiation, and apoptosis. Changes in the expression of circRNAs can cause the invasion and progression of tumors. Studies have shown that changes in the expression of circRNAs can be seen in acute lymphoid leukemia (ALL) and chronic lymphoid leukemia (CLL). The conducted studies aim to identify circRNAs whose expression has changed in these leukemias and their more precise function so that these circRNAs can be identified as biomarkers, prediction of patient prognosis, and treatment targets for ALL and CLL patients. In this study, we review the studies conducted on the role and function of circRNAs in ALL and CLL patients. The results of the studies show that there is a possibility of using circRNAs as biomarkers in the identification and treatment of patients in the future.
环状 RNA（circRNAs）是近年来受到广泛关注的单链 RNA。circRNAs 缺乏 5' 头和 3' 聚 A 尾。这种 RNA 的结构使它们能够抵抗核酸外切酶的消化。circRNAs 在不同的细胞中表达，并具有多种功能。circRNAs 的功能是通过海绵吸附 miRNA、改变基因表达和蛋白质产生来实现的。circRNAs 的表达在不同类型的癌症中发生变化，导致细胞生长、增殖、分化和凋亡的改变。circRNAs 表达的变化可导致肿瘤的侵袭和进展。研究表明，在急性淋巴细胞白血病（ALL）和慢性淋巴细胞白血病（CLL）中可以观察到 circRNAs 表达的变化。进行这些研究的目的是确定在这些白血病中表达发生变化的 circRNAs 及其更精确的功能，以便将这些 circRNAs 鉴定为 ALL 和 CLL 患者的生物标志物、预测患者预后和治疗靶点。在本研究中，我们回顾了关于 circRNAs 在 ALL 和 CLL 患者中的作用和功能的研究。研究结果表明，将来有可能将 circRNAs 用作鉴定和治疗患者的生物标志物。
