激素-谷氨酰胺代谢：内分泌相关癌症的关键调控轴。

Hormone-Glutamine Metabolism: A Critical Regulatory Axis in Endocrine-Related Cancers.

机构信息

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

Department of Gynecology, Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai 200010, China.

出版信息

Int J Mol Sci. 2022 Sep 3;23(17):10086. doi: 10.3390/ijms231710086.

DOI:10.3390/ijms231710086

PMID:36077501

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9456462/

Abstract

The endocrine-related cancers and hormones are undoubtedly highly interconnected. How hormones support or repress tumor induction and progression has been extensively profiled. Furthermore, advances in understanding the role of glutamine metabolism in mediating tumorigenesis and development, coupled with these in-depth studies on hormone (e.g., estrogen, progesterone, androgen, prostaglandin, thyroid hormone, and insulin) regulation of glutamine metabolism, have led us to think about the relationship between these three factors, which remains to be elucidated. Accordingly, in this review, we present an updated overview of glutamine metabolism traits and its influence on endocrine oncology, as well as its upstream hormonal regulation. More importantly, this hormone/glutamine metabolism axis may help in the discovery of novel therapeutic strategies for endocrine-related cancer.

摘要

内分泌相关癌症和激素无疑是高度相关的。激素如何支持或抑制肿瘤的诱导和进展已经被广泛研究。此外，对谷氨酰胺代谢在介导肿瘤发生和发展中的作用的理解的进步，加上对激素（如雌激素、孕激素、雄激素、前列腺素、甲状腺激素和胰岛素）调节谷氨酰胺代谢的深入研究，使我们开始思考这三个因素之间的关系，这一点仍有待阐明。因此，在这篇综述中，我们介绍了谷氨酰胺代谢特征及其对内分泌肿瘤学的影响，以及其上游激素调节的最新概述。更重要的是，这个激素/谷氨酰胺代谢轴可能有助于发现治疗内分泌相关癌症的新策略。