Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp. 72, 70-111 Szczecin, Poland.
Chair and Department of Functional Diagnostics and Physical Medicine, Pomeranian Medical University, Żołnierska 54, 71-210 Szczecin, Poland.
Int J Mol Sci. 2022 Sep 4;23(17):10127. doi: 10.3390/ijms231710127.
Stretching is one of the popular elements in physiotherapy and rehabilitation. When correctly guided, it can help minimize or slow down the disabling effects of chronic health conditions. Most likely, the benefits are associated with reducing inflammation; recent studies demonstrate that this effect from stretching is not just systemic but also local. In this review, we present the current body of knowledge on the anti-inflammatory properties of stretching at a molecular level. A total of 22 papers, focusing on anti-inflammatory and anti-cancer properties of stretching, have been selected and reviewed. We show the regulation of oxidative stress, the expression of pro- and anti-inflammatory genes and mediators, and remodeling of the extracellular matrix, expressed by changes in collagen and matrix metalloproteinases levels, in tissues subjected to stretching. We point out that a better understanding of the anti-inflammatory properties of stretching may result in increasing its importance in treatment and recovery from diseases such as osteoarthritis, systemic sclerosis, and cancer.
拉伸是物理治疗和康复中流行的元素之一。在正确引导的情况下，它可以帮助最小化或减缓慢性健康状况的致残影响。很可能，这些益处与减轻炎症有关；最近的研究表明，拉伸的这种作用不仅是全身性的，而且是局部性的。在这篇综述中，我们介绍了目前关于拉伸在分子水平上的抗炎特性的知识体系。共选择和回顾了 22 篇专注于拉伸的抗炎和抗癌特性的论文。我们展示了组织在拉伸作用下，氧化应激的调节、促炎和抗炎基因和介质的表达，以及细胞外基质的重塑，表现在胶原蛋白和基质金属蛋白酶水平的变化上。我们指出，更好地理解拉伸的抗炎特性可能会增加其在治疗和从骨关节炎、系统性硬化症和癌症等疾病中恢复的重要性。
