Shen Chwan-Li, Newman John W, Elmassry Moamen M, Borkowski Kamil, Chyu Ming-Chien, Kahathuduwa Chanaka, Neugebauer Volker, Watkins Bruce A
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX, United States.
Center of Excellence for Integrative Health, Texas Tech University Health Sciences Center, Lubbock, TX, United States.
Front Med (Lausanne). 2023 Aug 16;10:1210170. doi: 10.3389/fmed.2023.1210170. eCollection 2023.
Tai Chi (TC) controls pain through mind-body exercise and appears to alter inflammatory mediators. TC actions on lipid biomarkers associated with inflammation and brain neural networks in women with knee osteoarthritic pain were investigated.
A single-center, pre- and post-TC group (baseline and 8 wk) exercise pilot study in postmenopausal women with knee osteoarthritic pain was performed. 12 eligible women participated in TC group exercise. The primary outcome was liquid chromatography tandem mass spectrometry determination of circulating endocannabinoids (eCB) and oxylipins (OxL). Secondary outcomes were correlations between eCB and OxL levels and clinical pain/limitation assessments, and brain resting-state function magnetic resonance imaging (rs-fMRI).
Differences in circulating quantitative levels (nM) of pro-inflammatory OxL after TC were found in women. TC exercise resulted in lower OxL PGE and PGE and higher 12-HETE, LTB, and 12-HEPE compared to baseline. Pain assessment and eCB and OxL levels suggest crucial relationships between TC exercise, inflammatory markers, and pain. Higher plasma levels of eCB AEA, and 1, 2-AG were found in subjects with increased pain. Several eCB and OxL levels were positively correlated with left and right brain amygdala-medial prefrontal cortex functional connectivity.
TC exercise lowers pro-inflammatory OxL in women with knee osteoarthritic pain. Correlations between subject pain, functional limitations, and brain connectivity with levels of OxL and eCB showed significance. Findings indicate potential mechanisms for OxL and eCB and their biosynthetic endogenous PUFA precursors that alter brain connectivity, neuroinflammation, and pain.
ClinicalTrials.gov, identifier: NCT04046003.
太极拳（TC）通过身心锻炼控制疼痛，似乎还能改变炎症介质。本研究调查了太极拳对膝骨关节炎疼痛女性中与炎症和脑神经网络相关的脂质生物标志物的影响。
对绝经后膝骨关节炎疼痛女性进行了一项单中心、太极拳锻炼前后（基线和8周）的运动试点研究。12名符合条件的女性参加了太极拳锻炼组。主要结局是采用液相色谱串联质谱法测定循环内源性大麻素（eCB）和氧化脂质（OxL）。次要结局是eCB和OxL水平与临床疼痛/功能受限评估以及脑静息态功能磁共振成像（rs-fMRI）之间的相关性。
发现女性在进行太极拳锻炼后，促炎OxL的循环定量水平（nM）存在差异。与基线相比，太极拳锻炼导致OxL的前列腺素E（PGE）和前列腺素E降低，而12-羟基二十碳四烯酸（12-HETE）、白三烯B（LTB）和12-羟基二十碳五烯酸（12-HEPE）升高。疼痛评估以及eCB和OxL水平表明太极拳锻炼、炎症标志物和疼痛之间存在关键关系。疼痛增加的受试者血浆中eCB花生四烯乙醇胺（AEA）和1,2-二酰基甘油（1,2-AG）水平较高。几种eCB和OxL水平与左右脑杏仁核-内侧前额叶皮质功能连接呈正相关。
太极拳锻炼可降低膝骨关节炎疼痛女性的促炎OxL。受试者疼痛、功能受限以及脑连接性与OxL和eCB水平之间的相关性具有显著性。研究结果表明了OxL和eCB及其生物合成内源性多不饱和脂肪酸前体改变脑连接性、神经炎症和疼痛的潜在机制。
ClinicalTrials.gov，标识符：NCT04046003。
