Zhang Jingbing, Wang Geng, Huang Anyan, Cao Kexin, Tan Wei, Geng Hui, Lin Xiaosheng, Zhan Fulan, Wu Kusheng, Zheng Shukai, Liu Caixia
Department of Preventive Medicine, Shantou University Medical College, Shantou 515041, China.
Department of Thoracic Surgery, Cancer Hospital of Shantou University Medical College, Shantou 515041, China.
Cancers (Basel). 2022 Aug 31;14(17):4239. doi: 10.3390/cancers14174239.
We investigated the associations between multiple serum trace element levels and risk for esophageal squamous cell carcinoma (ESCC). A total of 185 ESCC patients and 191 healthy individuals were recruited in our study. The concentration of 13 trace elements (Al, V, Cr, Mn, Co, Ni, Cu, Zn, As, Se, Sr, Cd and Pb) in serum was determined with inductively coupled plasma mass spectrometry (ICP-MS). Logistic regression and the Probit extension of Bayesian Kernel Machine Regression (BKMR) models was established to explore the associations and the cumulative and mixed effects of multiple trace elements on ESCC. Three elements (Zn, Se and Sr) displayed a negative trend with risk for ESCC, and a significant overall effect of the mixture of Al, V, Mn, Ni, Zn, Se and Sr on ESCC was found, with the effects of V, Ni and Sr being nonlinear. Bivariate exposure-response interactions among these trace elements indicated a synergistic effect between Zn and Se, and an impactful difference of V combined with Ni, Sr or Zn. Our results indicate that Ni, V, Al, Mn, Zn, Se and Sr are associated with ESCC risk, providing additional evidence of the complex effects of trace elements disorder during the etiology of EC development.
我们研究了多种血清微量元素水平与食管鳞状细胞癌（ESCC）风险之间的关联。本研究共招募了185例ESCC患者和191名健康个体。采用电感耦合等离子体质谱法（ICP-MS）测定血清中13种微量元素（铝、钒、铬、锰、钴、镍、铜、锌、砷、硒、锶、镉和铅）的浓度。建立了逻辑回归模型和贝叶斯核机器回归（BKMR）模型的概率扩展模型，以探讨多种微量元素与ESCC之间的关联以及它们对ESCC的累积和混合效应。三种元素（锌、硒和锶）与ESCC风险呈负相关趋势，并且发现铝、钒、锰、镍、锌、硒和锶的混合物对ESCC具有显著的总体效应，其中钒、镍和锶的效应呈非线性。这些微量元素之间的双变量暴露-反应相互作用表明锌和硒之间存在协同效应，以及钒与镍、锶或锌联合存在显著差异。我们的研究结果表明，镍、钒、铝、锰、锌、硒和锶与ESCC风险相关，为食管癌发生病因中微量元素紊乱的复杂效应提供了额外证据。
