Department of Clinical Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang 621000, China.
Oxid Med Cell Longev. 2021 Jul 24;2021:4846951. doi: 10.1155/2021/4846951. eCollection 2021.
Many studies have identified causal and promotive roles of oxidative stress (OxS) and oxidative damage caused by OxS in the occurrence and progression of cancer. Many biomarkers in the blood circulation of patients may change correspondingly with the development of tumors. This study is aimed at investigating the correlation between OxS and serum trace element (TE) levels of patients with different types of cancer.
1143 different types of cancer patients and 178 healthy controls from Mar. 2018 to Aug. 2020 in Mianyang Central Hospital were involved in this study. Their levels of OxS parameters (including total oxidant status (TOS), total antioxidant status (TAS), and oxidant stress index (OSI)) and the concentrations of serum TEs (including Cu, Zn, Fe, and Se) were determined.
Compared with healthy controls, all types of cancer patients had higher TOS level (all < 0.001) and OSI level ( = 6.228 ~ 9.909, all < 0.001) and lower TAS level (all < 0.001). Compared with healthy controls, the changes of four TE levels in serum were different in different types of cancer patients, among which Cu increased in all groups, but there was no statistical difference in gastric and brain cancer; Se decreased in all groups, but there was no statistical difference in gastric, colorectal, esophageal, and other cancer; Zn was significantly decreased in breast cancer patients ( < 0.001); there was no statistical difference in the change of Fe in liver, kidney, and other cancer. Spearman correlation showed that the change of Cu concentration was most closely related to the three OxS parameters and was strongly correlated in the observed several types of tumors ( > 0.6). Multinomial logistic regression showed that the risks of different tumors are related to the level change of multiple TEs and OxS parameters (OR = 1.19 ~ 2.82, OR = 2.56 ~ 4.70, OR = 0.20 ~ 0.46, OR = 0.73 ~ 1.44, OR = 0.81 ~ 0.91, OR = 0.68 ~ 1.18, and OR = 0.22 ~ 0.45, all < 0.006).
The OxS exists in the occurrence and development of cancer, which may be related to the changes of certain trace elements. In order to evaluate OxS correctly, it is necessary to detect TAS and TOS and at the same time, their ratio OSI should be detected. Assessment of markers representing the overall level of OxS and TEs may guarantee improved the monitoring of disease occurrence and development risk in cancer patients.
许多研究已经确定了氧化应激（OxS）的因果和促进作用，以及 OxS 引起的氧化损伤在癌症的发生和发展中的作用。患者血液中的许多生物标志物可能会随着肿瘤的发展而相应变化。本研究旨在探讨不同类型癌症患者 OxS 与血清微量元素（TE）水平之间的相关性。
2018 年 3 月至 2020 年 8 月，绵阳市中心医院共纳入 1143 例不同类型癌症患者和 178 例健康对照者。检测其 OxS 参数（包括总氧化状态（TOS）、总抗氧化状态（TAS）和氧化应激指数（OSI））和血清 TE（包括 Cu、Zn、Fe 和 Se）浓度。
与健康对照组相比，所有类型的癌症患者的 TOS 水平（均<0.001）和 OSI 水平（=6.2289.909，均<0.001）均较高，而 TAS 水平（均<0.001）较低。与健康对照组相比，不同类型癌症患者血清中四种 TE 水平的变化不同，其中 Cu 在所有组中均升高，但在胃癌和脑癌中无统计学差异；Se 在所有组中均降低，但在胃癌、结直肠癌、食管癌等癌症中无统计学差异；乳腺癌患者 Zn 显著降低（<0.001）；肝癌、肾癌等癌症患者 Fe 变化无统计学差异。Spearman 相关性分析显示，Cu 浓度的变化与三种 OxS 参数的变化最为密切，在观察到的几种肿瘤中呈强相关性（>0.6）。多变量逻辑回归显示，不同肿瘤的风险与多种 TE 和 OxS 参数的水平变化有关（OR=1.192.82，OR=2.564.70，OR=0.200.46，OR=0.731.44，OR=0.810.91，OR=0.681.18，OR=0.220.45，均<0.006）。
OxS 存在于癌症的发生和发展中，这可能与某些微量元素的变化有关。为了正确评估 OxS，有必要同时检测 TAS 和 TOS，同时检测其比值 OSI。评估代表 OxS 和 TE 整体水平的标志物可能有助于提高对癌症患者疾病发生和发展风险的监测。
