Grelová Simona, Karasová Martina, Tóthová Csilla, Kisková Terézia, Baranová Darina, Lukáč Branislav, Fialkovičová Mária, Micháľová Alena, Kunay Lukáš, Svoboda Miroslav
Small Animal Clinic, University of Veterinary Medicine and Pharmacy, 04001 Košice, Slovakia.
Clinic of Ruminants, University of Veterinary Medicine and Pharmacy, 04001 Košice, Slovakia.
Animals (Basel). 2022 Aug 31;12(17):2247. doi: 10.3390/ani12172247.
Chronic kidney disease (CKD) is a common diagnosis in older cats, and its prevalence increases with age. Conventional indirect biomarkers of glomerular filtration rate (GFR) have their limitations, and are not efficient in detecting early decreases in glomerular filtration rate. Recently, symmetric dimethylarginine (SDMA) concentrations have been proposed as a novel biomarker of GFR for the early detection of CKD. This study discusses the relationship between SDMA, FGF 23 and previously used indicators of kidney function, mainly creatinine, urea and phosphate. Ninety-nine cats were included in this study. Based on their SDMA values, 48 cats had CKD and the remaining 51 cats were used as a healthy control group. Serum of these cats was assayed for creatinine, urea and phosphate concentrations as well as FGF 23 values, and correlations between them were evaluated. Cats with CKD had higher FGF 23 concentrations than healthy cats, and no correlation was found between FGF 23 and SDMA, nor between FGF 23 and phosphate. On the other hand, phosphate strongly correlated with SDMA, urea and creatinine, making it a possible independent factor of CKD progression.
慢性肾病（CKD）在老年猫中是一种常见的诊断疾病，其患病率随年龄增长而增加。肾小球滤过率（GFR）的传统间接生物标志物存在局限性，在检测肾小球滤过率早期下降方面效率不高。最近，对称二甲基精氨酸（SDMA）浓度已被提议作为一种用于早期检测CKD的GFR新型生物标志物。本研究探讨了SDMA、成纤维细胞生长因子23（FGF 23）与先前使用的肾功能指标（主要是肌酐、尿素和磷酸盐）之间的关系。本研究纳入了99只猫。根据它们的SDMA值，48只猫患有CKD，其余51只猫用作健康对照组。检测这些猫的血清中的肌酐、尿素和磷酸盐浓度以及FGF 23值，并评估它们之间的相关性。患有CKD的猫的FGF 23浓度高于健康猫，且未发现FGF 23与SDMA之间以及FGF 23与磷酸盐之间存在相关性。另一方面，磷酸盐与SDMA、尿素和肌酐密切相关，使其成为CKD进展的一个可能的独立因素。
