Lapsina Sandra, von Luckner Jennifer, Nagler Nicole, Müller Simon Franz, Müller Elisabeth, Schäfer Ingo
LABOKLIN GmbH and Co. KG, Steubenstraße 4, 97688 Bad Kissingen, Germany.
AniCura Ahlen, Bunsenstraße 20, 59229 Ahlen, Germany.
Animals (Basel). 2024 Jun 3;14(11):1670. doi: 10.3390/ani14111670.
Fibroblast growth factor (FGF)-23 is a phosphaturic hormone. An association between increasing FGF-23 levels and progression of chronic kidney disease (CKD) was documented in cats, dogs, and humans. The information regarding reference intervals (RIs) of FGF-23 in cats is limited. We aimed to establish RIs in a large cohort of clinically healthy cats and to investigate correlations with sex and age. A total of 118 cats with unremarkable complete blood count and serum chemistry profile were included. Clinically sick cats, cats with concurrent diseases, suspicion of CKD, or receiving renal diets were excluded. FGF-23 concentrations were measured with the FGF-23 ELISA Kit. RIs were calculated using the reference interval advisor software 2.1 (Microsoft Excel). FGF-23 concentrations were correlated with sex and age. The RI for FGF-23 concentrations spanned 85.8 to 387.0 pg/mL (90% confidence interval: lower limit 40.5 to 103.9 pg/mL, upper limit: 354.6 to 425.0 pg/mL). No significant relationships (r = 0.044) were detected with age ( = 0.081) or sex ( = 0.191). Other studies of the same diagnostic assay calculated RIs of 56 to 700 pg/mL in 79 cats and <336 pg/mL in 108 cats, and in concordance with the present study, did not detect any correlation with sex or age.
成纤维细胞生长因子（FGF）-23是一种促尿磷排泄激素。在猫、狗和人类中，均已证实FGF-23水平升高与慢性肾脏病（CKD）进展之间存在关联。关于猫FGF-23参考区间（RI）的信息有限。我们旨在建立一大群临床健康猫的RI，并研究其与性别和年龄的相关性。总共纳入了118只全血细胞计数和血清化学指标均无异常的猫。排除临床患病猫、患有并发疾病、疑似CKD或接受肾脏专用日粮的猫。使用FGF-23 ELISA试剂盒测量FGF-23浓度。使用参考区间顾问软件2.1（Microsoft Excel）计算RI。FGF-23浓度与性别和年龄相关。FGF-23浓度的RI范围为85.8至387.0 pg/mL（90%置信区间：下限40.5至103.9 pg/mL，上限：354.6至425.0 pg/mL）。未检测到与年龄（P = 0.081）或性别（P = 0.191）有显著关系（r = 0.044）。同一诊断检测的其他研究计算出79只猫的RI为56至700 pg/mL，108只猫的RI<336 pg/mL，并且与本研究一致，未检测到与性别或年龄有任何相关性。
