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催乳素在狒狒眼部的表达。

Prolactin Expression in the Baboon () Eye.

作者信息

Garza-Rodríguez María Lourdes, Rodríguez-Sanchez Iram Pablo, González-Álvarez Rafael, Luna Maricela, Burciaga-Flores Carlos Horacio, Alcorta-Nuñez Fernando, Solis-Coronado Orlando, Bautista de Lucio Víctor Manuel, Ramírez-Correa Genaro A, Vidal-Gutiérrez Oscar, Pérez-Ibave Diana Cristina

机构信息

Servicio de Oncología, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey 64440, Mexico.

Laboratorio de Fisiología Molecular y Estructural, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolás de los Garza 66455, Mexico.

出版信息

Animals (Basel). 2022 Sep 3;12(17):2288. doi: 10.3390/ani12172288.

DOI:10.3390/ani12172288
PMID:36078009
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9455022/
Abstract

UNLABELLED

Prolactin (PRL) is a hormone expressed in lactotrophs cells of the pituitary gland in primates. Extra pituitary expression of PRL has been reported, including the eye; however, expression in the developing eye of primates is limited. The aim of the study was determining the expression of and receptor () (mRNAs and proteins) in adult and fetal baboon () ocular tissues.

METHODS

We analyzed PRL and PRLR in baboon eyes tissues by immunofluorescence. The mRNAs of and were detected by RT-PCR, cDNA was cloned, and sequenced. Furthermore, we performed a phylogenetic analysis to identify the evolutionary forces that underlie the divergence of and primate genes.

RESULTS

We observed the expression of PRL and PRLR (mRNAs and proteins) in all retinal cell lineages of fetal and adult baboon. and fit the hypothesis of evolutionary purifying gene selection.

CONCLUSIONS

mRNA and protein of PRL and PRLR are expressed in fetal and adult baboon retinal tissue. PRL may trigger autocrine and paracrine-specific actions in retinal cell lines.

摘要

未标记

催乳素（PRL）是一种在灵长类动物垂体催乳素细胞中表达的激素。已有报道称PRL存在垂体外表达，包括眼部；然而，在灵长类动物发育中的眼睛中的表达有限。本研究的目的是确定成年和胎儿狒狒眼部组织中催乳素及其受体（PRLR）（mRNA和蛋白质）的表达情况。

方法

我们通过免疫荧光分析狒狒眼组织中的PRL和PRLR。通过RT-PCR检测PRL和PRLR的mRNA，克隆cDNA并进行测序。此外，我们进行了系统发育分析，以确定灵长类动物PRL和PRLR基因分歧背后的进化力量。

结果

我们在胎儿和成年狒狒的所有视网膜细胞谱系中观察到PRL和PRLR（mRNA和蛋白质）的表达。PRL和PRLR符合进化纯化基因选择的假设。

结论

PRL和PRLR的mRNA和蛋白质在胎儿和成年狒狒视网膜组织中表达。PRL可能在视网膜细胞系中触发自分泌和旁分泌特异性作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc5/9455022/13930c06830e/animals-12-02288-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc5/9455022/41d628f64874/animals-12-02288-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc5/9455022/9fff41c3ce1e/animals-12-02288-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc5/9455022/13930c06830e/animals-12-02288-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc5/9455022/41d628f64874/animals-12-02288-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc5/9455022/9fff41c3ce1e/animals-12-02288-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dfc5/9455022/13930c06830e/animals-12-02288-g005.jpg

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