Hasselmark L, Malmgren R, Hannerz J
Cephalalgia. 1987 Jun;7(2):87-92. doi: 10.1046/j.1468-2982.1987.0702087.x.
Because serotonin, released from platelets, has been suggested to initiate migraine, a decreased platelet serotonin content, attained by a reduced intake of serotonin and the serotonin precursor tryptophan, might be beneficial. In the brain, however, increased serotonin levels, achieved by a high carbohydrate intake, are probably favourable. Seven migraine patients (four with classic, three with common migraine) were placed on a carbohydrate-rich diet, low in protein-tryptophan. Three of the four classic migraineurs, but none of the common migraineurs, noted improvement in their migraine. Platelet serotonin uptake was within the normal range both before and at the end of the diet period. The apparent positive effect in the classic migraineurs could be due to a reduced intake of migraine-precipitating foods and/or increased brain serotonin levels.
由于血小板释放的血清素被认为会引发偏头痛，通过减少血清素及其前体色氨酸的摄入量来降低血小板血清素含量可能有益。然而，在大脑中，通过高碳水化合物摄入实现的血清素水平升高可能是有利的。七名偏头痛患者（四名典型偏头痛患者，三名普通偏头痛患者）采用富含碳水化合物、低蛋白色氨酸的饮食。四名典型偏头痛患者中有三名症状改善，但普通偏头痛患者无一改善。在饮食期开始前和结束时，血小板血清素摄取均在正常范围内。典型偏头痛患者的明显积极效果可能是由于偏头痛诱发食物摄入量减少和/或大脑血清素水平升高。
