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居住在“萨科河河谷”（意大利拉齐奥地区）的年轻男性的精子分子改变和严重异常：一项初步研究。

Molecular Alterations and Severe Abnormalities in Spermatozoa of Young Men Living in the "Valley of Sacco River" (Latium, Italy): A Preliminary Study.

机构信息

Department of Biology, University of Naples Federico II, Via Cinthia, 21, 80126 Naples, Italy.

Department of Precision Medicine, School of Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

出版信息

Int J Environ Res Public Health. 2022 Sep 3;19(17):11023. doi: 10.3390/ijerph191711023.

DOI:10.3390/ijerph191711023
PMID:36078739
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9518305/
Abstract

The Valley of Sacco River (VSR) (Latium, Italy) is an area with large-scale industrial chemical production that has led over time to significant contamination of soil and groundwater with various industrial pollutants, such as organic pesticides, dioxins, organic solvents, heavy metals, and particularly, volatile organic compounds (VOCs). In the present study, we investigated the potential impact of VOCs on the spermatozoa of healthy young males living in the VSR, given the prevalent presence of several VOCs in the semen of these individuals. To accomplish this, spermiograms were conducted followed by molecular analyses to assess the content of sperm nuclear basic proteins (SNBPs) in addition to the protamine-histone ratio and DNA binding of these proteins. We found drastic alterations in the spermatozoa of these young males living in the VSR. Alterations were seen in sperm morphology, sperm motility, sperm count, and protamine/histone ratios, and included significant reductions in SNBP-DNA binding capacity. Our results provide preliminary indications of a possible correlation between the observed alterations and the presence of specific VOCs.

摘要

意大利拉齐奥大区的萨科河河谷（VSR）是一个拥有大规模化工生产的地区，随着时间的推移，这里的土壤和地下水已经受到了各种工业污染物的严重污染，包括有机农药、二恶英、有机溶剂、重金属，以及特别的挥发性有机化合物（VOCs）。在本研究中，鉴于在这些个体的精液中普遍存在多种 VOCs，我们调查了 VOCs 对居住在 VSR 的健康年轻男性精子的潜在影响。为了实现这一目标，我们进行了精子分析，并进行了分子分析，以评估精子核碱性蛋白（SNBP）的含量、这些蛋白质的鱼精蛋白-组蛋白比例以及 DNA 结合情况。我们发现，居住在 VSR 的这些年轻男性的精子发生了严重的变化。在精子形态、精子活力、精子计数和鱼精蛋白/组蛋白比例方面都发生了变化，并且 SNBP-DNA 结合能力显著降低。我们的结果初步表明，观察到的变化与特定 VOCs 的存在之间可能存在相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb82/9518305/03904955b428/ijerph-19-11023-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb82/9518305/433574f35e20/ijerph-19-11023-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb82/9518305/9e4687b65324/ijerph-19-11023-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb82/9518305/1df0c1b90677/ijerph-19-11023-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb82/9518305/78363989d6cf/ijerph-19-11023-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb82/9518305/eb2e827bbfa3/ijerph-19-11023-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb82/9518305/eab2f85cd483/ijerph-19-11023-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb82/9518305/03904955b428/ijerph-19-11023-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb82/9518305/433574f35e20/ijerph-19-11023-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb82/9518305/9e4687b65324/ijerph-19-11023-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb82/9518305/1df0c1b90677/ijerph-19-11023-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb82/9518305/78363989d6cf/ijerph-19-11023-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb82/9518305/eb2e827bbfa3/ijerph-19-11023-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb82/9518305/eab2f85cd483/ijerph-19-11023-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb82/9518305/03904955b428/ijerph-19-11023-g007.jpg

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