生活方式改变干预对生活在意大利高污染地区的健康年轻男性精液质量的影响：FASt随机对照试验

Effects of a Lifestyle Change Intervention on Semen Quality in Healthy Young Men Living in Highly Polluted Areas in Italy: The FASt Randomized Controlled Trial.

作者信息

Montano Luigi, Ceretti Elisabetta, Donato Francesco, Bergamo Paolo, Zani Claudia, Viola Gaia Claudia Viviana, Notari Tiziana, Pappalardo Sebastiana, Zani Danilo, Ubaldi Stefania, Bollati Valentina, Consales Claudia, Leter Giorgio, Trifuoggi Marco, Amoresano Angela, Lorenzetti Stefano

机构信息

Andrology Unit and Service of Lifestyle Medicine in UroAndrology, Local Health Authority (ASL) Salerno, Coordination Unit of the network for Environmental and Reproductive Health (EcoFoodFertility Project), Italy "Oliveto Citra Hospital", Salerno, Italy; PhD Program in Evolutionary Biology and Ecology, University of Rome Tor Vergata, Rome, Italy.

Unit of Hygiene, Epidemiology and Public Health, and Unit of Urology, Department of Medical and Surgical Specialties Radiological, University of Brescia, Brescia, Italy.

出版信息

Eur Urol Focus. 2022 Jan;8(1):351-359. doi: 10.1016/j.euf.2021.01.017. Epub 2021 Feb 10.

DOI:10.1016/j.euf.2021.01.017

PMID:33579652

Abstract

BACKGROUND

Human semen quality is affected by lifestyle and environmental factors.

OBJECTIVE

To evaluate the short-term effects of a diet and physical activity intervention on semen quality of healthy young men living in highly polluted areas of Italy.

DESIGN, SETTING, AND PARTICIPANTS: A randomized controlled trial was conducted. Healthy young men were assigned to an intervention or a control group.

INTERVENTION

A 4-mo Mediterranean diet and moderate physical activity program.

OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS

The primary outcomes were sperm concentration, motility and morphology, concentration of round cells, and semen total antioxidant capacity. Secondary outcomes were adherence to Mediterranean diet and physical activity. All outcomes were measured twice, at the enrollment (t0) and at the end of the intervention (t4).

RESULTS AND LIMITATIONS

A total of 263 individuals attended all visits, and underwent examinations and laboratory analyses: 137 in the intervention group and 126 in the control group. The adherence to Mediterranean diet and physical activity level increased more in the intervention group than in the control group from t0 to t4. Sperm concentration, total and progressive motility, and proportion of normal morphology cells increased in the intervention group but decreased in the control group, with statistically significant differences between the two groups at t4. The total antioxidant capacity increased in the intervention group but decreased in the control group, from t0 to t4.

CONCLUSIONS

Study results showed that an intervention based on Mediterranean diet and regular physical activity can determine an improvement of semen quality in healthy young men.

PATIENT SUMMARY

Our study aimed to evaluate the effect of a lifestyle intervention on semen quality of healthy young men. We assigned the 263 enrolled individuals to an intervention or a control group. The intervention group followed a 4-mo Mediterranean diet and moderate physical activity program, at the end of which the participants showed an improvement of semen quality parameters.

摘要

背景

人类精液质量受生活方式和环境因素影响。

目的

评估饮食和体育活动干预对生活在意大利高污染地区的健康年轻男性精液质量的短期影响。

设计、地点和参与者：进行了一项随机对照试验。健康年轻男性被分配到干预组或对照组。

干预措施

为期4个月的地中海饮食和适度体育活动计划。

结果测量和统计分析

主要结果是精子浓度、活力和形态、圆形细胞浓度以及精液总抗氧化能力。次要结果是对地中海饮食和体育活动的依从性。所有结果在入组时（t0）和干预结束时（t4）各测量一次。

结果与局限性

共有263人参加了所有访视，并接受了检查和实验室分析：干预组137人，对照组126人。从t0到t4，干预组对地中海饮食和体育活动水平的依从性比对照组增加得更多。干预组的精子浓度、总活力和前向运动能力以及正常形态细胞比例增加，而对照组则下降，两组在t4时有统计学显著差异。从t0到t4，干预组的总抗氧化能力增加，而对照组下降。