Cabrera C V, Martinez-Arias A, Bate M
Cell. 1987 Jul 31;50(3):425-33. doi: 10.1016/0092-8674(87)90496-x.
The expression of a subset of homologous genes of the AS-C is required during embryogenesis and metamorphosis for proper neural development. Here we study the expression of three of these genes (T3, T4, and T5) and show that their transcripts accumulate at the blastoderm stage in periodic patterns coincident with the dorsoventral extent of the neuroectoderm. Subsequent expression is in partially overlapping patterns that correlate with the segregation of neuroblasts. These genes are not transcribed in neurons. We also show that a deficiency for the AS-C prevents the appearance of at least one identified class of neuroblasts. We propose that the AS-C is part of a network of genes responsible for the segregation of neuroblasts.
AS-C同源基因的一个子集在胚胎发生和变态过程中对于正常的神经发育是必需的。在这里，我们研究了其中三个基因（T3、T4和T5）的表达，结果表明它们的转录本在胚盘阶段以周期性模式积累，与神经外胚层的背腹范围一致。随后的表达模式部分重叠，这与神经母细胞的分离相关。这些基因不在神经元中转录。我们还表明，AS-C的缺陷会阻止至少一类已确定的神经母细胞的出现。我们提出，AS-C是负责神经母细胞分离的基因网络的一部分。
