Sato Keiji, Jujo Tatsuya, Sekine Reio, Uchiyama Naoto, Kakehashi Kota, Kogo Jiro
Department of Ophthalmology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan.
J Clin Med. 2022 Aug 28;11(17):5055. doi: 10.3390/jcm11175055.
We investigate-d whether biomarkers such as red blood cell hematocrit (Hct), platelet count (PLT), mean platelet volume (MPV), and platelet distribution width (PDW) are useful prognostic indicators of postoperative macular edema (ME) after vitrectomy for proliferative diabetic retinopathy (PDR). A total of 42 eyes of 42 patients with PDR who underwent vitrectomy between January 2018 and May 2020 were analyzed retrospectively. We divided them into two groups according to whether treatment was required for postoperative ME and compared the relationship between Hct, PLT, MPV, and PDW and the onset of postoperative ME. The group that received postoperative treatment (group T) comprised 11 eyes of 11 patients, and the group that did not (group N) comprised 31 eyes of 31 patients. The age (years) was 52.0 ± 3.1 in group T and 60.0 ± 11.6 in group N. When appropriate statistical analysis was performed for comparison between groups, significant differences were found in age ( = 0.05), insulin use ( = 0.03), preoperative intraocular pressure ( = 0.05), diastolic blood pressure ( = 0.03), and Hct ( = 0.04). Multivariate logistic regression analysis was performed, and a significant difference was found in Hct ( = 0.02). These results suggest that Hct might be useful as a predictor of ME after PDR surgery.
我们研究了诸如红细胞压积（Hct）、血小板计数（PLT）、平均血小板体积（MPV）和血小板分布宽度（PDW）等生物标志物是否是增殖性糖尿病视网膜病变（PDR）玻璃体切除术后黄斑水肿（ME）的有用预后指标。回顾性分析了2018年1月至2020年5月期间接受玻璃体切除术的42例PDR患者的42只眼。我们根据术后ME是否需要治疗将他们分为两组，并比较了Hct、PLT、MPV和PDW与术后ME发生之间的关系。接受术后治疗的组（T组）包括11例患者的11只眼，未接受治疗的组（N组）包括31例患者的31只眼。T组年龄（岁）为52.0±3.1，N组为60.0±11.6。对两组间进行比较的适当统计分析时，发现年龄（P = 0.05）、胰岛素使用情况（P = 0.03）、术前眼压（P = 0.05）、舒张压（P = 0.03）和Hct（P = 0.04）存在显著差异。进行多因素逻辑回归分析时，发现Hct存在显著差异（P = 0.02）。这些结果表明，Hct可能作为PDR手术后ME的预测指标。
