Department of Internal Medicine IV, University Hospital of Tübingen, Tübingen, Germany.
Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Zentrum München at the University of Tübingen, Tübingen, Germany.
Sci Rep. 2019 Feb 4;9(1):1303. doi: 10.1038/s41598-018-38002-7.
Niacin inhibits fatty acid flux from adipose tissue to liver, reduces hepatic triglyceride synthesis and increases hepatic lipid oxidation. Thus, niacin may have a role in the regulation of liver fat content in humans. We tested if dietary intake of niacin predicts change of liver fat content during a lifestyle intervention. To this end, we estimated the composition of diet from diaries of 202 healthy subjects at risk of type 2 diabetes undergoing lifestyle intervention comprising physical activity and diet counselling. Total-, subcutaneous- and visceral adipose tissue mass were measured by magnetic resonance (MR) tomography and liver fat content by H-MR spectroscopy at baseline and after 9 months of follow-up. Among fat compartments, liver fat content showed the largest decrease (-32%, p < 0.0001). High baseline niacin intake predicted a larger decrease of liver fat (p = 0.004). Subjects in the highest quartile of niacin intake at baseline also had the largest decrease of liver fat (1:-10%; 2:-27%; 3:-35%; 4:-37%). Among 58 subjects with nonalcoholic fatty liver disease (NAFLD) at baseline, NAFLD resolved in 23 subjects during the lifestyle intervention. For one standard deviation increase in niacin intake, the odds ratio for resolution of NAFLD was 1.77 (95% CI, 1.00-3.43). High dietary niacin intake may have a favorable effect on the reduction of liver fat during lifestyle intervention.
烟酸可抑制脂肪组织向肝脏转移，减少肝脏甘油三酯的合成，增加肝脏脂质氧化。因此，烟酸可能在调节人体肝脏脂肪含量方面发挥作用。我们检测了饮食烟酸摄入量是否可预测生活方式干预期间肝脏脂肪含量的变化。为此，我们通过对 202 名有 2 型糖尿病风险的健康受试者的日记进行饮食成分估计，这些受试者正在接受包括体育活动和饮食咨询的生活方式干预。在基线和 9 个月随访时，采用磁共振（MR）断层摄影术测量总脂肪、皮下脂肪和内脏脂肪量，并用 H-MR 光谱法测量肝脏脂肪含量。在所有脂肪隔室中，肝脏脂肪含量下降幅度最大（-32%，p<0.0001）。较高的基线烟酸摄入量预示着肝脏脂肪减少幅度更大（p=0.004）。基线时烟酸摄入量最高四分位数的受试者肝脏脂肪减少幅度最大（1：-10%；2：-27%；3：-35%；4：-37%）。在基线时有非酒精性脂肪性肝病（NAFLD）的 58 名受试者中，23 名受试者在生活方式干预期间 NAFLD 得到缓解。烟酸摄入量增加一个标准差，NAFLD 缓解的比值比为 1.77（95% CI，1.00-3.43）。高膳食烟酸摄入量可能对生活方式干预中肝脏脂肪的减少有有利影响。
