Department of Parasitology, Chulalongkorn University Faculty of Medicine, Bangkok 10330, Thailand.
Department of Preventive and Social Medicine, School of Global Health, Chulalongkorn University Faculty of Medicine, Bangkok 10330, Thailand.
Nutrients. 2022 Sep 5;14(17):3661. doi: 10.3390/nu14173661.
Pharmacologic and non-pharmacologic treatments for stroke are essential but can be costly or harmful, whereas probiotics are a promising alternative. This scoping review aimed to synthesize the and evidence of probiotics on stroke-related neurological, biochemical, and histochemical outcomes.
A systematic review was conducted in PubMed, Embase, and Cochrane Central Register of Clinical Trials (CENTRAL) up to 7 May 2021. Titles and abstracts were screened and assessed by two independent reviewers. The initial screening criteria aimed to include studies using probiotics, prebiotics, and symbiotics both and for the prevention and/or treatment of stroke.
Of 6293 articles, 4990 passed the initial screen after excluding duplication articles, of which 36 theme-related full texts were assessed and 13 were included in this review. No studies passed the criteria to be included in this review. Probiotics can ameliorate neurological deficits and show their anti-inflammation and anti-oxidative properties. Decreased loss of cerebral volume and inhibition of neuronal apoptosis were revealed in histopathological evidence.
There are potential cognitive benefits of probiotic supplementation, especially among animal models, on decreasing cerebral volume, increasing neurological score, and decreasing the inflammatory response. However, further investigation is needed to validate these conclusions in various populations.
脑卒中的药物和非药物治疗至关重要，但可能成本高昂或存在风险，而益生菌是一种有前途的替代方法。本范围综述旨在综合益生菌对脑卒中相关神经、生化和组织化学结局的作用和证据。
我们在 PubMed、Embase 和 Cochrane 临床试验中央注册库（CENTRAL）中进行了系统评价，检索截至 2021 年 5 月 7 日。两名独立的审查员筛选和评估了标题和摘要。最初的筛选标准旨在纳入使用益生菌、益生元和合生元预防和/或治疗脑卒中的研究。
在 6293 篇文章中，排除重复文章后有 4990 篇通过了初始筛选，其中 36 篇主题相关的全文进行了评估，13 篇被纳入本综述。没有符合标准的随机对照试验被纳入本综述。益生菌可以改善神经功能缺损，并显示其抗炎和抗氧化特性。组织病理学证据表明，脑体积减少和神经元凋亡减少。
益生菌补充剂可能具有认知益处，特别是在动物模型中，可以减少脑体积、增加神经评分和减少炎症反应。然而，需要进一步的研究来验证这些结论在不同人群中的适用性。
