School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, China.
Molecules. 2022 Aug 30;27(17):5570. doi: 10.3390/molecules27175570.
To search for efficient agricultural antifungal lead compounds, 39 derivatives were designed, synthesized, and evaluated for their antifungal activities. The structures of target compounds were fully characterized by H NMR, C NMR, and MS spectra. The preliminary bioassays revealed that some compounds exhibited excellent antifungal activities in vitro. For example, the minimum inhibitory concentration (MIC) of compound against was 1.95 µg mL, and the minimum inhibitory concentration (MIC) of compound against was 1.95 µg mL. Therefore, compounds and were identified as the most promising candidates for further study.
为了寻找高效的农业抗真菌先导化合物，设计、合成了 39 个衍生物，并评估了它们的抗真菌活性。目标化合物的结构通过 1H NMR、13C NMR 和 MS 谱图进行了充分的表征。初步的生物测定结果表明，一些化合物在体外表现出优异的抗真菌活性。例如，化合物 对 的最小抑菌浓度（MIC）为 1.95 µg mL，化合物 对 的最小抑菌浓度（MIC）为 1.95 µg mL。因此，化合物 和 被确定为进一步研究的最有希望的候选物。
