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超分子策略在抗菌表面的应用。

A Supramolecular Approach to Antimicrobial Surfaces.

机构信息

Department of Chemistry, University of Pavia, Viale Torquato Taramelli 12, 27100 Pavia, Italy.

Department of Drug Sciences, University of Pavia, Viale Torquato Taramelli 12, 27100 Pavia, Italy.

出版信息

Molecules. 2022 Sep 5;27(17):5731. doi: 10.3390/molecules27175731.

DOI:10.3390/molecules27175731
PMID:36080495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9457607/
Abstract

In this paper, we report on the preparation of Imidazole-functionalized glass surfaces, demonstrating the ability of a dinuclear Cu(II) complex of a macrocyclic ligand to give a "cascade" interaction with the deprotonated forms of grafted imidazole moieties. In this way, we realized a prototypal example of an antimicrobial surface based on a supramolecular approach, obtaining a neat microbicidal effect using low amounts of the described copper complex.

摘要

本文报道了咪唑功能化玻璃表面的制备,展示了大环配体双核 Cu(II) 配合物与接枝咪唑部分的去质子形式发生“级联”相互作用的能力。通过这种方式,我们基于超分子方法实现了一个典型的抗菌表面原型,使用低浓度的所描述的铜配合物获得了明显的杀菌效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9d9/9457607/e6043e43db8b/molecules-27-05731-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9d9/9457607/b6821abe8e01/molecules-27-05731-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9d9/9457607/573aaf93480c/molecules-27-05731-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9d9/9457607/b5fb29c8c001/molecules-27-05731-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9d9/9457607/265e5c159ede/molecules-27-05731-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9d9/9457607/e08b2b8cdf62/molecules-27-05731-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9d9/9457607/e6043e43db8b/molecules-27-05731-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9d9/9457607/b6821abe8e01/molecules-27-05731-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9d9/9457607/573aaf93480c/molecules-27-05731-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9d9/9457607/b5fb29c8c001/molecules-27-05731-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9d9/9457607/265e5c159ede/molecules-27-05731-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9d9/9457607/e08b2b8cdf62/molecules-27-05731-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e9d9/9457607/e6043e43db8b/molecules-27-05731-g005.jpg

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本文引用的文献

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Chemistry. 2021 Jan 18;27(4):1306-1310. doi: 10.1002/chem.202004272. Epub 2020 Dec 16.
2
Self-Assembled Monolayers of Copper Sulfide Nanoparticles on Glass as Antibacterial Coatings.玻璃上硫化铜纳米颗粒自组装单分子层作为抗菌涂层
Nanomaterials (Basel). 2020 Feb 18;10(2):352. doi: 10.3390/nano10020352.
3
High Bactericidal Self-Assembled Nano-Monolayer of Silver Sulfadiazine on Hydroxylated Material Surfaces.
磺胺嘧啶银在羟基化材料表面的高杀菌自组装纳米单层
Materials (Basel). 2019 Aug 28;12(17):2761. doi: 10.3390/ma12172761.
4
Metal nanoparticles: understanding the mechanisms behind antibacterial activity.金属纳米颗粒:了解抗菌活性背后的机制
J Nanobiotechnology. 2017 Oct 3;15(1):65. doi: 10.1186/s12951-017-0308-z.
5
Antibiofilm activity of a monolayer of silver nanoparticles anchored to an amino-silanized glass surface.固载于氨基硅烷化玻璃表面的单层银纳米粒子的抗生物膜活性。
Biomaterials. 2014 Feb;35(6):1779-88. doi: 10.1016/j.biomaterials.2013.11.047. Epub 2013 Dec 7.
6
A review of the clinical implications of anti-infective biomaterials and infection-resistant surfaces.抗感染生物材料和抗感染表面的临床意义综述。
Biomaterials. 2013 Nov;34(33):8018-29. doi: 10.1016/j.biomaterials.2013.07.048. Epub 2013 Aug 8.
7
Coordination chemistry for antibacterial materials: a monolayer of a Cu(2+) 2,2'-bipyridine complex grafted on a glass surface.抗菌材料的配位化学:接枝在玻璃表面的 Cu(2+) 2,2'-联吡啶单层
Dalton Trans. 2013 Apr 7;42(13):4552-60. doi: 10.1039/c2dt32607h.
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