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玻璃上硫化铜纳米颗粒自组装单分子层作为抗菌涂层

Self-Assembled Monolayers of Copper Sulfide Nanoparticles on Glass as Antibacterial Coatings.

作者信息

Gargioni Chiara, Borzenkov Mykola, D'Alfonso Laura, Sperandeo Paola, Polissi Alessandra, Cucca Lucia, Dacarro Giacomo, Grisoli Pietro, Pallavicini Piersandro, D'Agostino Agnese, Taglietti Angelo

机构信息

Department of Chemistry, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.

Nanomedicine Center, Department of Physics, University of Milano-Bicocca, Piazza dell'Ateneo Nuovo, 20126 Milan, Italy.

出版信息

Nanomaterials (Basel). 2020 Feb 18;10(2):352. doi: 10.3390/nano10020352.

DOI:10.3390/nano10020352
PMID:32085548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7075189/
Abstract

We developed an easy and reproducible synthetic method to graft a monolayer of copper sulfide nanoparticles (CuS NP) on glass and exploited their particular antibacterial features. Samples were fully characterized showing a good stability, a neat photo-thermal effect when irradiated in the Near InfraRed (NIR) region (in the so called "biological window"), and the ability to release controlled quantities of copper in water. The desired antibacterial activity is thus based on two different mechanisms: (i) slow and sustained copper release from CuS NP-glass samples, (ii) local temperature increase caused by a photo-thermal effect under NIR laser irradiation of CuS NP-glass samples. This behavior allows promising in vivo applications to be foreseen, ensuring a "static" antibacterial protection tailored to fight bacterial adhesion in the critical timescale of possible infection and biofilm formation. This can be reinforced, when needed, by a photo-thermal action switchable on demand by an NIR light.

摘要

我们开发了一种简便且可重复的合成方法，用于在玻璃上接枝单层硫化铜纳米颗粒（CuS NP），并利用其独特的抗菌特性。对样品进行了全面表征，结果表明其具有良好的稳定性，在近红外（NIR）区域（即所谓的“生物窗口”）照射时具有明显的光热效应，以及在水中释放可控量铜的能力。因此，所需的抗菌活性基于两种不同的机制：（i）CuS NP-玻璃样品缓慢且持续地释放铜，（ii）在CuS NP-玻璃样品的近红外激光照射下，光热效应导致局部温度升高。这种特性使得有望预见其在体内的应用，确保在可能发生感染和生物膜形成的关键时间尺度上，提供一种针对对抗细菌粘附的“静态”抗菌保护。如有需要，可通过近红外光按需切换的光热作用来增强这种保护。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/7075189/2a78a156083d/nanomaterials-10-00352-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/7075189/0ccff5e41c27/nanomaterials-10-00352-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/7075189/4c7e3dc0010c/nanomaterials-10-00352-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/7075189/03183ad7dac7/nanomaterials-10-00352-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/7075189/608f6b1767f4/nanomaterials-10-00352-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/7075189/efa0d2c5dc04/nanomaterials-10-00352-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/7075189/2a78a156083d/nanomaterials-10-00352-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/7075189/0ccff5e41c27/nanomaterials-10-00352-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/7075189/4c7e3dc0010c/nanomaterials-10-00352-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/7075189/03183ad7dac7/nanomaterials-10-00352-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/7075189/608f6b1767f4/nanomaterials-10-00352-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/7075189/efa0d2c5dc04/nanomaterials-10-00352-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec3/7075189/2a78a156083d/nanomaterials-10-00352-g005.jpg

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