Elaine Angela Alysia, Krisyanto Steven Imanuel, Hasanah Aliya Nur
Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM 21.5, Sumedang 45363, Indonesia.
Drug Development Study Center, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung Sumedang KM 21.5, Sumedang 45363, Indonesia.
Polymers (Basel). 2022 Aug 26;14(17):3498. doi: 10.3390/polym14173498.
A molecularly imprinted polymer (MIP) is a synthetic polymer that has characteristics such as natural receptors which are able to interact and bind to a specific molecule that is used as a template in the MIP polymerization process. MIPs have been widely developed because of the need for more selective, effective, and efficient methods for sample preparation, identification, isolation, and separation. The MIP compositions consist of a template, monomer, crosslinker, initiator, and porogenic solvent. Generally, MIPs are only synthesized using one type of monomer (mono-functional monomer); however, along with the development of MIPs, MIPs began to be synthesized using two types of monomers to improve the performance of MIPs. MIPs used for identification, separation, and molecular analysis have the most applications in solid-phase extraction (SPE) and as biochemical sensors. Until now, no review article has discussed the various studies carried out in recent years in relation to the synthesis of dual-functional monomer MIPs. This review is necessary, as an improvement in the performance of MIPs still needs to be explored, and a dual-functional monomer strategy is one way of overcoming the current performance limitations. In this review article, we discuss the techniques commonly used in the synthesis of dual-functional monomer MIPs, and the use of dual-functional monomer MIPs as sorbents in the MI-SPE method and as detection elements in biochemical sensors. The application of dual-functional monomer MIPs showed better selectivity and adsorption capacity in these areas when compared to mono-functional monomer MIPs. However, the combination of functional monomers must be selected properly, in order to achieve an effective synergistic effect and produce the ideal MIP characteristics. Therefore, studies regarding the synergistic effect of the MIP combination still need to be carried out to obtain MIPs with superior characteristics.
分子印迹聚合物（MIP）是一种合成聚合物，具有天然受体的特性，能够与特定分子相互作用并结合，该特定分子在MIP聚合过程中用作模板。由于需要更具选择性、有效性和高效性的样品制备、鉴定、分离和提纯方法，MIP得到了广泛的发展。MIP的组成包括模板、单体、交联剂、引发剂和致孔溶剂。一般来说，MIP仅使用一种类型的单体（单官能单体）合成；然而，随着MIP的发展，开始使用两种类型的单体来合成MIP，以提高其性能。用于鉴定、分离和分子分析的MIP在固相萃取（SPE）和作为生化传感器方面应用最为广泛。到目前为止，还没有综述文章讨论近年来关于双功能单体MIP合成的各种研究。这篇综述是必要的，因为仍需要探索提高MIP性能的方法，而双功能单体策略是克服当前性能限制的一种途径。在这篇综述文章中，我们讨论了双功能单体MIP合成中常用的技术，以及双功能单体MIP在MI-SPE方法中作为吸附剂和在生化传感器中作为检测元件的应用。与单功能单体MIP相比，双功能单体MIP在这些领域的应用表现出更好的选择性和吸附能力。然而，必须正确选择功能单体的组合，以实现有效的协同效应并产生理想的MIP特性。因此，仍需要开展关于MIP组合协同效应的研究，以获得具有优异特性的MIP。
