Kaspute Greta, Ramanavicius Arunas, Prentice Urte
Department of Nanotechnology, State Research Institute Center for Physical Sciences and Technology (FTMC), Sauletekio Av. 3, LT-10257 Vilnius, Lithuania.
Department of Personalised Medicine, State Research Institute Centre for Innovative Medicine, Santariskes St. 5, LT-08410 Vilnius, Lithuania.
Polymers (Basel). 2024 Aug 28;16(17):2441. doi: 10.3390/polym16172441.
Essential oils (EOs) hold therapeutic potential, but their conventional delivery systems have some limitations. This review focuses on the critical review and discussion of research related to EO delivery systems. The review also explores how molecular imprinting technologies (MIT) can advance EO delivery. MIT offer several techniques, namely covalent, non-covalent, and semi-covalent imprinting, creating targeted cavities that selectively bind and release EOs. These approaches promise significant advantages including increased selectivity, controlled release, and protection from environmental degradation. However, some challenges related to the stability and biocompatibility of MIPs remain unsolved. Integrating nanotechnology through methods like nanoparticle imprinting and some lithographic techniques seems promising to overcome these limitations. Some recently established models and systems used for EO-related research are paving the way for a more efficient and targeted EO delivery approach to harnessing the therapeutic power of EOs. Therefore, some recent and future research seems promising, and eventually it will increase the effectiveness of MIP-based EO delivery systems.
精油具有治疗潜力,但其传统给药系统存在一些局限性。本综述重点对与精油给药系统相关的研究进行批判性审视和讨论。该综述还探讨了分子印迹技术(MIT)如何推动精油给药。分子印迹技术提供了几种技术,即共价、非共价和半共价印迹,可创建能选择性结合和释放精油的靶向空腔。这些方法具有显著优势,包括提高选择性、控释以及防止环境降解。然而,与分子印迹聚合物的稳定性和生物相容性相关的一些挑战仍未解决。通过纳米颗粒印迹和一些光刻技术等方法整合纳米技术,似乎有望克服这些局限性。一些最近建立的用于精油相关研究的模型和系统,正在为采用更高效、靶向性更强的精油给药方法以发挥精油的治疗功效铺平道路。因此,一些近期和未来的研究似乎很有前景,最终将提高基于分子印迹聚合物的精油给药系统的有效性。