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我们来调音？从核壳型到云型肝素/二氧化硅杂化纳米结构

Shall We Tune? From Core-Shell to Cloud Type Nanostructures in Heparin/Silica Hybrids.

作者信息

Pota Giulio, Vitiello Giuseppe, Venezia Virginia, Della Sala Francesca, Borzacchiello Assunta, Costantini Aniello, Paduano Luigi, Cavalcanti Leide P, Tescione Fabiana, Silvestri Brigida, Luciani Giuseppina

机构信息

Department of Chemical, Materials and Production Engineering, University of Naples Federico II, Piazzale Tecchio 80, 80125 Naples, Italy.

Institute of Polymers, Composites and Biomaterials, National Research Council, (IPCB-CNR), 80125 Naples, Italy.

出版信息

Polymers (Basel). 2022 Aug 30;14(17):3568. doi: 10.3390/polym14173568.

DOI:10.3390/polym14173568
PMID:36080642
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9460005/
Abstract

Heparin plays multiple biological roles depending on the availability of active sites strongly influenced by the conformation and the structure of polysaccharide chains. Combining different components at the molecular scale offers an extraordinary chance to easily tune the structural organization of heparin required for exploring new potential applications. In fact, the combination of different material types leads to challenges that cannot be achieved by each single component. In this study, hybrid heparin/silica nanoparticles were synthesized, and the role of silica as a templating agent for heparin supramolecular organization was investigated. The effect of synthesis parameters on particles compositions was deeply investigated by Fourier Transform Infrared Spectroscopy (FTIR) and Thermogravimetric Analysis (TGA). Transmission Electron Microscopy (TEM) reveals a different supramolecular organization of both components, leading to amazing organic-inorganic nanoparticles with different behavior in drug encapsulation and release. Furthermore, favorable biocompatibility for healthy human dermal fibroblasts (HDF) and tumor HS578T cells has been assessed, and a different biological behavior was observed, ascribed to different surface charge and morphology of synthesized nanoparticles.

摘要

肝素发挥多种生物学作用，这取决于受多糖链构象和结构强烈影响的活性位点的可用性。在分子尺度上组合不同成分提供了一个绝佳机会，可以轻松调节探索新潜在应用所需的肝素结构组织。事实上，不同材料类型的组合带来了单个成分无法实现的挑战。在本研究中，合成了肝素/二氧化硅杂化纳米颗粒，并研究了二氧化硅作为肝素超分子组织模板剂的作用。通过傅里叶变换红外光谱（FTIR）和热重分析（TGA）深入研究了合成参数对颗粒组成的影响。透射电子显微镜（TEM）揭示了两种成分不同的超分子组织，形成了在药物包封和释放方面具有不同行为的惊人有机-无机纳米颗粒。此外，还评估了对健康人皮肤成纤维细胞（HDF）和肿瘤HS578T细胞的良好生物相容性，并观察到不同的生物学行为，这归因于合成纳米颗粒的不同表面电荷和形态。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e6b/9460005/5754d49bf37f/polymers-14-03568-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e6b/9460005/e771aeaf4357/polymers-14-03568-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e6b/9460005/6e9983cac730/polymers-14-03568-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e6b/9460005/e7137a2250d9/polymers-14-03568-g007.jpg
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