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纳米材料在结核病 DNA 疫苗传递中的应用：历史回顾与现状分析。

Nanomaterials in tuberculosis DNA vaccine delivery: historical perspective and current landscape.

机构信息

National Engineering Research Centre of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing, China.

Department of Laboratory Medicine, Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.

出版信息

Drug Deliv. 2022 Dec;29(1):2912-2924. doi: 10.1080/10717544.2022.2120565.

DOI:10.1080/10717544.2022.2120565
PMID:36081335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9467597/
Abstract

Vaccinations, especially DNA vaccines that promote host immunity, are the most effective interventions for tuberculosis (TB) control. However, the vaccine delivery system exhibits a significant impact on the protective effects of the vaccine. Recently, effective nanomaterial-based delivery systems (including nanoparticles, nanogold, nanoliposomes, virus-like particles, and virus carriers) have been developed for DNA vaccines to control TB. This review highlights the historical development of various nanomaterial-based delivery systems for TB DNA vaccines, along with the emerging technologies. Nanomaterial-based vaccine delivery systems could enhance the efficacy of TB vaccination; therefore, this summary could guide nanomaterial selection for optimal and safe vaccine delivery, facilitating the design and development of highly effective TB vaccines.

摘要

疫苗接种，特别是促进宿主免疫的 DNA 疫苗，是结核病（TB）控制最有效的干预措施。然而，疫苗传递系统对疫苗的保护效果有重大影响。最近，已经开发出有效的基于纳米材料的 DNA 疫苗传递系统（包括纳米颗粒、纳米金、纳米脂质体、类病毒颗粒和病毒载体）来控制结核病。本综述强调了各种基于纳米材料的结核病 DNA 疫苗传递系统的历史发展，以及新兴技术。基于纳米材料的疫苗传递系统可以提高结核病疫苗接种的效果；因此，本总结可以指导纳米材料的选择，以实现最佳和安全的疫苗传递，促进高效结核病疫苗的设计和开发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68f/9467597/2598ed246d48/IDRD_A_2120565_F0008_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68f/9467597/9f1acf6cba9d/IDRD_A_2120565_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68f/9467597/6e9d6a9cf1a2/IDRD_A_2120565_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68f/9467597/a91f4664df1d/IDRD_A_2120565_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68f/9467597/76f52e60dfd2/IDRD_A_2120565_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68f/9467597/bce2bcc26eb0/IDRD_A_2120565_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68f/9467597/f3f6aa75ce8b/IDRD_A_2120565_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68f/9467597/54c9053a843d/IDRD_A_2120565_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68f/9467597/2598ed246d48/IDRD_A_2120565_F0008_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68f/9467597/9f1acf6cba9d/IDRD_A_2120565_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68f/9467597/6e9d6a9cf1a2/IDRD_A_2120565_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68f/9467597/a91f4664df1d/IDRD_A_2120565_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68f/9467597/76f52e60dfd2/IDRD_A_2120565_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68f/9467597/bce2bcc26eb0/IDRD_A_2120565_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68f/9467597/f3f6aa75ce8b/IDRD_A_2120565_F0006_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68f/9467597/54c9053a843d/IDRD_A_2120565_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68f/9467597/2598ed246d48/IDRD_A_2120565_F0008_C.jpg

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Economic evaluation of patient costs associated with tuberculosis diagnosis and care in Solomon Islands.所罗门群岛结核诊断和治疗相关患者费用的经济评价。
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