Wingless/integrase-1 信号通路在变应性哮喘和儿科肺部疾病中的作用。
Wingless/integrase-1 signaling in allergic asthma and pediatric lung diseases.
机构信息
Department of Pediatrics.
Department of Anesthesiology, Medicine, and Physiology and Cellular Biophysics, Columbia University Medical Center, New York, New York, USA.
出版信息
Curr Opin Pediatr. 2022 Dec 1;34(6):572-579. doi: 10.1097/MOP.0000000000001173. Epub 2022 Sep 9.
PURPOSE OF REVIEW
To provide an update on the current understanding of the role of wingless/integrase-1 (Wnt) signaling in pediatric allergic asthma and other pediatric lung diseases.
RECENT FINDINGS
The Wnt signaling pathway is critical for normal lung development. Genetic and epigenetic human studies indicate a link between Wnt signaling and the development and severity of asthma in children. Mechanistic studies using animal models of allergic asthma demonstrate a key role for Wnt signaling in allergic airway inflammation and remodeling. More recently, data on bronchopulmonary dysplasia (BPD) pathogenesis points to the Wnt signaling pathway as an important regulator.
SUMMARY
Current data indicates that the Wnt signaling pathway is an important mediator in allergic asthma and BPD pathogenesis. Further studies are needed to characterize the roles of individual Wnt signals in childhood disease, and to identify potential novel therapeutic targets to slow or prevent disease processes.
目的综述
提供关于无翅型整合素-1（Wnt）信号在小儿过敏性哮喘和其他小儿肺部疾病中的作用的最新认识。
最近发现
Wnt 信号通路对正常肺发育至关重要。遗传和表观遗传的人类研究表明 Wnt 信号与儿童哮喘的发展和严重程度之间存在关联。使用过敏性哮喘动物模型的机制研究表明，Wnt 信号在过敏性气道炎症和重塑中起关键作用。最近，有关支气管肺发育不良（BPD）发病机制的数据表明 Wnt 信号通路是一个重要的调节因子。
总结
目前的数据表明，Wnt 信号通路是过敏性哮喘和 BPD 发病机制中的重要介质。需要进一步研究以确定个体 Wnt 信号在儿童疾病中的作用，并确定潜在的新的治疗靶点以减缓或预防疾病进程。
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