重新审视哮喘治疗学：关注 WNT 信号转导。

Revisiting asthma therapeutics: focus on WNT signal transduction.

机构信息

Department of Molecular Pharmacology, University of Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, The Netherlands.

出版信息

Drug Discov Today. 2018 Jan;23(1):49-62. doi: 10.1016/j.drudis.2017.09.001. Epub 2017 Sep 7.

DOI:10.1016/j.drudis.2017.09.001

PMID:28890197

Abstract

Asthma is a complex disease of the airways that develops as a consequence of both genetic and environmental factors. This interaction has highlighted genes important in early life, particularly those that control lung development, such as the Wingless/Integrase-1 (WNT) signalling pathway. Although aberrant WNT signalling is involved with an array of human conditions, it has received little attention within the context of asthma. Yet it is highly relevant, driving events involved with inflammation, airway remodelling, and airway hyper-responsiveness (AHR). In this review, we revisit asthma therapeutics by examining whether WNT signalling is a valid therapeutic target for asthma.

摘要

哮喘是一种气道的复杂疾病，它是由遗传和环境因素共同作用而发展形成的。这种相互作用突出了生命早期重要的基因，特别是那些控制肺发育的基因，如无翅型/整合酶-1（WNT）信号通路。虽然异常的 WNT 信号参与了一系列人类疾病，但在哮喘的背景下，它并没有受到太多关注。然而，它与炎症、气道重塑和气道高反应性（AHR）等相关事件密切相关。在这篇综述中，我们通过研究 WNT 信号是否是哮喘的一个有效治疗靶点，重新审视了哮喘的治疗方法。