Felix Nicole, Ayers Emmeline, Verghese Joe, Blumen Helena M
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
Departments of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
Innov Aging. 2022 Aug 8;6(5):igac048. doi: 10.1093/geroni/igac048. eCollection 2022.
The motoric cognitive risk syndrome (MCR) is a predementia syndrome characterized by slow gait and cognitive complaint. The relationship between MCR and social support-a potentially modifiable risk factor of dementia-is currently unknown. The current study aimed to determine whether MCR incidence varies as a function of social support in aging.
We examined MCR incidence in 506 community-dwelling older adults ( Age 76.59; 57.3% female) without MCR or dementia at baseline. We quantified perceived levels of social support with the Medical Outcomes Study Social Support Survey, incorporating four different categories of support: (a) emotional/informational support, (b) tangible support, (c) affectionate support, and (d) positive social interactions. We used Cox regression analyses, adjusted for age, sex, race/ethnicity, education, marital status, comorbidities, and global cognition, to estimate hazard ratios (aHR) with 95% confidence intervals (CIs).
Over a median follow-up time of 2.5 years (range = 1-7 years), 38 participants (9.8%) developed MCR. Increased tangible support decreased the risk of MCR by 30% (aHR: 0.70, 95% CI: 0.53-0.92, = .011). Increased overall social support decreased the risk of MCR by 33% (aHR: 0.67, 95% CI: 0.46-0.98, = .038). Other subcategories of social support were not associated with a decreased risk of MCR ( > .05).
Higher levels of tangible social support, as well as overall social support, were associated with reduced risk for MCR in older adults. Increasing social support may be a promising avenue of intervention for reducing the risk of MCR, dementia, and other forms of cognitive decline.
运动认知风险综合征(MCR)是一种以步态缓慢和认知主诉为特征的痴呆前综合征。MCR与社会支持(痴呆潜在的可改变风险因素)之间的关系目前尚不清楚。本研究旨在确定MCR发病率是否随老年人社会支持情况而变化。
我们对506名社区居住的老年人(年龄76.59岁;57.3%为女性)进行了研究,这些老年人在基线时无MCR或痴呆。我们使用医学结局研究社会支持调查对感知到的社会支持水平进行量化,该调查包含四类不同的支持:(a)情感/信息支持,(b)实际支持,(c)亲情支持,以及(d)积极的社会互动。我们采用Cox回归分析,并对年龄、性别、种族/民族、教育程度、婚姻状况、合并症和整体认知进行校正,以估计风险比(aHR)及95%置信区间(CI)。
在中位随访时间2.5年(范围=1 - 7年)内,38名参与者(9.8%)发生了MCR。实际支持增加使MCR风险降低30%(aHR:0.70,95%CI:0.53 - 0.92,P = 0.011)。总体社会支持增加使MCR风险降低33%(aHR:0.67,95%CI:0.46 - 0.98,P = 0.038)。社会支持的其他子类别与MCR风险降低无关(P > 0.05)。
更高水平的实际社会支持以及总体社会支持与老年人MCR风险降低相关。增加社会支持可能是降低MCR、痴呆及其他形式认知衰退风险的一个有前景的干预途径。