Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
J Alzheimers Dis. 2021;81(2):651-665. doi: 10.3233/JAD-201576.
The motoric cognitive risk (MCR) syndrome is a pre-clinical stage of dementia characterized by slow gait and cognitive complaint. Yet, the brain substrates of MCR are not well established.
To examine cortical thickness, volume, and surface area associated with MCR in the MCR-Neuroimaging Consortium, which harmonizes image processing/analysis of multiple cohorts.
Two-hundred MRIs (M age 72.62 years; 47.74%female; 33.17%MCR) from four different cohorts (50 each) were first processed with FreeSurfer 6.0, and then analyzed using multivariate and univariate general linear models with 1,000 bootstrapped samples (n-1; with resampling). All models adjusted for age, sex, education, white matter lesions, total intracranial volume, and study site.
Overall, cortical thickness was lower in individuals with MCR than in those without MCR. There was a trend in the same direction for cortical volume (p = 0.051). Regional cortical thickness was also lower among individuals with MCR than individuals without MCR in prefrontal, insular, temporal, and parietal regions.
Cortical atrophy in MCR is pervasive, and include regions previously associated with human locomotion, but also social, cognitive, affective, and motor functions. Cortical atrophy in MCR is easier to detect in cortical thickness than volume and surface area because thickness is more affected by healthy and pathological aging.
运动认知风险（MCR）综合征是一种痴呆前阶段，其特征为步态缓慢和认知主诉。然而，MCR 的大脑基础尚未明确。
在 MCR 神经影像学联盟中，检查与 MCR 相关的皮质厚度、体积和表面积，该联盟协调了多个队列的图像处理/分析。
来自四个不同队列的 200 个 MRI（平均年龄 72.62 岁；47.74%为女性；33.17%为 MCR）首先用 FreeSurfer 6.0 进行处理，然后使用多元和单变量通用线性模型进行分析，每个模型有 1000 个 bootstrap 样本（n-1；采用重采样）。所有模型均调整了年龄、性别、教育程度、白质病变、总颅内体积和研究地点。
总体而言，MCR 个体的皮质厚度低于无 MCR 个体。皮质体积也呈现出相同的趋势（p=0.051）。MCR 个体的前额叶、岛叶、颞叶和顶叶等区域的皮质厚度也低于无 MCR 个体。
MCR 中的皮质萎缩是普遍存在的，包括先前与人类运动、社会、认知、情感和运动功能相关的区域。与体积和表面积相比，MCR 中的皮质萎缩在皮质厚度中更容易检测到，因为厚度更受健康和病理性衰老的影响。
