运动认知风险综合征与老年人的死亡率风险。
Motoric cognitive risk syndrome and risk of mortality in older adults.
机构信息
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
出版信息
Alzheimers Dement. 2016 May;12(5):556-64. doi: 10.1016/j.jalz.2015.08.167. Epub 2015 Nov 3.
INTRODUCTION
Cognitive impairment is associated with increased mortality. We examined the association between motoric cognitive risk (MCR) syndrome, a predementia syndrome characterized by slow gait and cognitive complaints, and survival.
METHODS
A total of 11,867 nondemented participants aged >65 years from three established cohort studies in the United States and Europe were screened for MCR. Mortality risk of MCR was assessed with Cox and logistic regression models.
RESULTS
At baseline, 836 (7.0%) participants had MCR. Over a median follow-up of 28 months, 1603 participants died (758 in first 2 years). MCR was associated with increased mortality overall (adjusted hazard ratio, 1.69; 95% confidence interval [CI], 1.46-1.96) and 2-year mortality (adjusted odds ratio, 1.89; 95% CI, 1.50-2.38). The association remained after accounting for established mortality risk factors as well as baseline gait speed and memory performance.
DISCUSSION
MCR is associated with increased mortality. Older adults should be screened for MCR to identify at-risk individuals for dementia and death.
简介
认知障碍与死亡率增加有关。我们研究了运动认知风险（MCR）综合征与生存之间的关系，MCR 综合征是一种以步态缓慢和认知主诉为特征的前驱痴呆综合征。
方法
共有来自美国和欧洲的三项既定队列研究的 11867 名年龄>65 岁的非痴呆参与者接受了 MCR 的筛查。使用 Cox 和逻辑回归模型评估 MCR 的死亡风险。
结果
在基线时，836 名（7.0%）参与者患有 MCR。在中位数为 28 个月的中位随访期间，有 1603 名参与者死亡（前 2 年有 758 名死亡）。MCR 与总体死亡率增加相关（调整后的危险比，1.69；95%置信区间[CI]，1.46-1.96）和 2 年死亡率（调整后的优势比，1.89；95%CI，1.50-2.38）。即使考虑到既定的死亡风险因素以及基线步态速度和记忆表现，这种关联仍然存在。
讨论
MCR 与死亡率增加有关。应筛查老年患者的 MCR，以识别有痴呆和死亡风险的个体。
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