Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
J Am Geriatr Soc. 2020 Jul;68(7):1554-1559. doi: 10.1111/jgs.16424. Epub 2020 Jun 2.
Personality traits have been shown to be associated with the risk of dementia; less is known about their association with pre-dementia syndromes. The aim of the present study was to examine the role of personality traits as predictors of incident pre-dementia, motoric cognitive risk (MCR), and mild cognitive impairment (MCI) syndromes.
We prospectively examined the association between five personality traits (neuroticism, extraversion, conscientiousness, agreeableness, and openness) and the risk of incident MCR or MCI. MCR builds on MCI operational definitions, substituting the cognitive impairment criterion with slow gait, and it is associated with increased risk for both Alzheimer's disease and vascular dementia.
Community based.
Nondemented participants (n = 524; 62% women) aged 65 years and older.
Cox proportional hazard analysis, adjusted for demographics and disease burden, was used to evaluate the risk of each pre-dementia syndrome based on baseline personality traits, measured using the Big Five Inventory.
Over a median follow-up of 3 years, 38 participants developed incident MCR, and 69 developed incident MCI (41 non-amnestic and 28 amnestic subtypes). Openness was associated with a reduced risk of developing incident MCR (adjusted hazard ratio [aHR] = .94; 95% confidence interval [CI] = .89-.99), whereas neuroticism was associated with an increased risk of incident non-amnestic MCI (aHR = 1.06; 95% CI = 1.01-1.11). These associations remained significant even after considering the confounding effects of lifestyle or mood. None of the personality traits were associated with MCI overall or amnestic MCI.
These findings provide evidence of a distinct relationship between personality traits and development of specific pre-dementia syndromes. J Am Geriatr Soc 68:1554-1559, 2020.
已证实人格特质与痴呆风险相关；但对于其与痴呆前期综合征的关联，人们了解较少。本研究旨在探究人格特质作为痴呆前期、运动认知风险（MCR）和轻度认知障碍（MCI）综合征发病预测因子的作用。
我们前瞻性地研究了 5 种人格特质（神经质、外向性、尽责性、宜人性和开放性）与 MCR 或 MCI 发病风险之间的关联。MCR 基于 MCI 的操作性定义，用缓慢的步态替代认知障碍标准，与阿尔茨海默病和血管性痴呆的风险增加相关。
社区。
无痴呆的参与者（n=524；62%为女性），年龄≥65 岁。
使用大五人格量表测量人格特质，采用 Cox 比例风险分析，调整人口统计学和疾病负担因素，评估基于基线人格特质的每个痴呆前期综合征的发病风险。
在中位 3 年的随访期间，38 名参与者出现 MCR 发病，69 名参与者出现 MCI 发病（41 名非遗忘型和 28 名遗忘型亚型）。开放性与发生 MCR 的风险降低相关（校正后危险比[aHR]=0.94；95%置信区间[CI]为 0.89-0.99），而神经质与发生非遗忘型 MCI 的风险增加相关（aHR=1.06；95%CI 为 1.01-1.11）。即使考虑到生活方式或情绪的混杂影响，这些关联仍然显著。没有任何人格特质与 MCI 或遗忘型 MCI 总体相关。
这些发现为人格特质与特定痴呆前期综合征发展之间的独特关系提供了证据。
美国老年学会杂志 68:1554-1559, 2020.
