Mennen Anne C, Nastase Samuel A, Yeshurun Yaara, Hasson Uri, Norman Kenneth A
Princeton Neuroscience Institute, Princeton University, Princeton, NJ, 08540-1010, USA.
School of Psychological Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.
Neuroimage Rep. 2022 Sep;2(3). doi: 10.1016/j.ynirp.2022.100111. Epub 2022 Jul 2.
We explored the potential of using real-time fMRI (rt-fMRI) neurofeedback training to bias interpretations of naturalistic narrative stimuli. Participants were randomly assigned to one of two possible conditions, each corresponding to a different interpretation of an ambiguous spoken story. While participants listened to the story in the scanner, neurofeedback was used to reward neural activity corresponding to the assigned interpretation. After scanning, final interpretations were assessed. While neurofeedback did not change story interpretations on average, participants with higher levels of decoding accuracy during the neurofeedback procedure were more likely to adopt the assigned interpretation; additional control conditions are needed to establish the role of individualized feedback in driving this result. While naturalistic stimuli introduce a unique set of challenges in providing effective and individualized neurofeedback, we believe that this technique holds promise for individualized cognitive therapy.
我们探索了使用功能磁共振成像实时神经反馈训练（rt-fMRI）来偏向对自然主义叙事刺激的解读的潜力。参与者被随机分配到两种可能的条件之一，每种条件对应于对一个模棱两可的口头故事的不同解读。当参与者在扫描仪中听故事时，神经反馈被用于奖励与指定解读相对应的神经活动。扫描后，评估最终解读。虽然神经反馈平均而言并没有改变故事解读，但在神经反馈过程中解码准确率较高的参与者更有可能采用指定的解读；需要额外的对照条件来确定个性化反馈在推动这一结果中的作用。虽然自然主义刺激在提供有效和个性化的神经反馈方面带来了一系列独特的挑战，但我们相信这种技术在个性化认知治疗方面具有前景。
