Sathyanesan Monica, Newton Samuel S
Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, United States.
Sioux Falls VA Healthcare System, Sioux Falls, SD, United States.
Front Mol Neurosci. 2022 Aug 23;15:958797. doi: 10.3389/fnmol.2022.958797. eCollection 2022.
A significant body of research has demonstrated that antidepressants regulate neurotrophic factors and that neurotrophins themselves are capable of independently producing antidepressant-like effects. While brain derived neurotrophic factor (BDNF) remains the best studied molecule in this context, there are several structurally diverse trophic factors that have shown comparable behavioral effects, including basic fibroblast growth factor (FGF-2), insulin-like growth factor 1 (IGF-1) and vascular endothelial growth factor (VEGF). In this review we discuss the structural and biochemical signaling aspects of these neurotrophic factors with antidepressant activity. We also include a discussion on a cytokine molecule erythropoietin (EPO), widely known and prescribed as a hormone to treat anemia but has recently been shown to function as a neurotrophic factor in the central nervous system (CNS).
大量研究表明，抗抑郁药可调节神经营养因子，且神经营养素自身能够独立产生类抗抑郁作用。虽然在此背景下脑源性神经营养因子（BDNF）仍是研究最多的分子，但有几种结构不同的营养因子也显示出类似的行为效应，包括碱性成纤维细胞生长因子（FGF-2）、胰岛素样生长因子1（IGF-1）和血管内皮生长因子（VEGF）。在本综述中，我们讨论了这些具有抗抑郁活性的神经营养因子的结构和生化信号传导方面。我们还讨论了一种细胞因子分子促红细胞生成素（EPO），它作为一种治疗贫血的激素广为人知且被广泛应用，但最近已被证明在中枢神经系统（CNS）中发挥神经营养因子的作用。
