Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232-2050, USA; Department of Pharmacology, Vanderbilt University, Nashville, TN 37240-7933, USA.
Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232-2050, USA; Department of Pharmacology, Vanderbilt University, Nashville, TN 37240-7933, USA.
Cell. 2022 Jan 6;185(1):62-76. doi: 10.1016/j.cell.2021.12.003. Epub 2021 Dec 27.
Brain-derived neurotrophic factor (BDNF) is a neuropeptide that plays numerous important roles in synaptic development and plasticity. While its importance in fundamental physiology is well established, studies of BDNF often produce conflicting and unclear results, and the scope of existing research makes the prospect of setting future directions daunting. In this review, we examine the importance of spatial and temporal factors on BDNF activity, particularly in processes such as synaptogenesis, Hebbian plasticity, homeostatic plasticity, and the treatment of psychiatric disorders. Understanding the fundamental physiology of when, where, and how BDNF acts and new approaches to control BDNF signaling in time and space can contribute to improved therapeutics and patient outcomes.
脑源性神经营养因子（BDNF）是一种神经肽，在突触发育和可塑性中发挥着许多重要作用。虽然其在基础生理学中的重要性已得到充分证实，但 BDNF 的研究经常产生相互矛盾和不清楚的结果，并且现有研究的范围使得设定未来方向的前景令人生畏。在这篇综述中，我们研究了时空因素对 BDNF 活性的重要性，特别是在突触发生、赫布可塑性、同型可塑性和精神疾病治疗等过程中。了解 BDNF 作用的时间、地点和方式的基础生理学以及控制 BDNF 信号在时间和空间上的新方法，可以有助于改善治疗方法和患者预后。
