Wolfsberger Christina H, Hoeller Nina, Suppan Ena, Schwaberger Bernhard, Urlesberger Berndt, Nakstad Britt, Pichler Gerhard
Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.
Research Unit for Neonatal Micro- and Macrocirculation, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.
Front Pediatr. 2022 Aug 23;10:940915. doi: 10.3389/fped.2022.940915. eCollection 2022.
Peripheral fractional oxygen extraction (pFOE) measured with near-infrared spectroscopy (NIRS) in combination with venous occlusion is of increasing interest in term and preterm neonates.
The aim was to perform a systematic qualitative review of literature on the clinical use of pFOE in term and preterm neonates and on the changes in pFOE values over time.
A systematic search of PubMed, Embase and Medline was performed using following terms: newborn, infant, neonate, preterm, term, near-infrared spectroscopy, NIRS, oximetry, spectroscopy, tissue, muscle, peripheral, arm, calf, pFOE, OE, oxygen extraction, fractional oxygen extraction, peripheral perfusion and peripheral oxygenation. Additional articles were identified by manual search of cited references. Only studies in human neonates were included.
Nineteen studies were identified describing pFOE measured with NIRS in combination with venous occlusion. Nine studies described pFOE measured on the forearm and calf at different time points after birth, both in stable preterm and term neonates without medical/respiratory support or any pathological findings. Nine studies described pFOE measured at different time points in sick preterm and term neonates presenting with signs of infection/inflammation, anemia, arterial hypotension, patent ductus arteriosus, asphyxia or prenatal tobacco exposure. One study described pFOE both, in neonates with and without pathological findings.
This systematic review demonstrates that pFOE may provide additional insight into peripheral perfusion and oxygenation, as well as into disturbances of microcirculation caused by centralization in preterm and term neonates with different pathological findings.
[https://www.crd.york.ac.uk/prospero/], identifier [CRD42021249235].
近红外光谱（NIRS）结合静脉闭塞测量的外周分数氧摄取（pFOE）在足月儿和早产儿中越来越受到关注。
旨在对关于pFOE在足月儿和早产儿中的临床应用以及pFOE值随时间变化的文献进行系统的定性综述。
使用以下术语对PubMed、Embase和Medline进行系统检索：新生儿、婴儿、早产儿、足月儿、近红外光谱、NIRS、血氧测定法、光谱学、组织、肌肉、外周、手臂、小腿、pFOE、OE、氧摄取、分数氧摄取、外周灌注和外周氧合。通过手动检索引用的参考文献确定其他文章。仅纳入人类新生儿的研究。
共确定了19项描述用NIRS结合静脉闭塞测量pFOE的研究。9项研究描述了在出生后不同时间点对稳定的早产儿和足月儿在前臂和小腿测量的pFOE，这些新生儿无医疗/呼吸支持或任何病理发现。9项研究描述了在患有感染/炎症、贫血、动脉低血压、动脉导管未闭、窒息或产前烟草暴露体征的患病早产儿和足月儿中不同时间点测量的pFOE。1项研究描述了有和无病理发现的新生儿的pFOE情况。
本系统综述表明，pFOE可能为外周灌注和氧合以及不同病理发现的早产儿和足月儿因中心性循环改变引起的微循环紊乱提供更多见解。
