pFOE或pFTOE作为新生儿外周微循环受损的早期标志物。
pFOE or pFTOE as an Early Marker for Impaired Peripheral Microcirculation in Neonates.
作者信息
Hoeller Nina, Wolfsberger Christina H, Pfurtscheller Daniel, Binder-Heschl Corinna, Schwaberger Bernhard, Urlesberger Berndt, Pichler Gerhard
机构信息
Division of Neonatology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, 8036 Graz, Austria.
Research Unit for Neonatal Micro- and Macrocirculation, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, 8036 Graz, Austria.
出版信息
Children (Basel). 2022 Jun 16;9(6):898. doi: 10.3390/children9060898.
BACKGROUND
Peripheral-muscle-fractional-oxygen-extraction (pFOE) and peripheral-muscle-fractional-tissue-oxygen-extraction (pFTOE) are often equated, since both parameters are measured with near-infrared-spectroscopy (NIRS) and estimate oxygen extraction in the tissue. The aim was to investigate the comparability of both parameters and their potential regarding detection of impaired microcirculation.
METHODS
Term and preterm neonates with NIRS measurements of upper (UE) and lower extremities (LE) were included. pFOE was calculated out of peripheral-muscle-mixed-venous-saturation (pSvO), measured with NIRS and venous occlusion, and arterial oxygen saturation (SpO). pFTOE was calculated out of peripheral-muscle-tissue-oxygen-saturation and SpO. Both parameters were compared using Wilcoxon-Signed-Rank-test and Bland-Altman plots.
RESULTS
341 NIRS measurements were included. pFOE was significantly higher than pFTOE in both locations. Bland-Altman plots revealed limited comparability, especially with increasing oxygen extraction with higher values of pFOE compared to pFTOE.
CONCLUSION
The higher pFOE compared to pFTOE suggests a higher potential of pFOE to detect impaired microcirculation, especially when oxygen extraction is elevated.
背景
外周肌肉氧摄取分数（pFOE）和外周肌肉组织氧摄取分数（pFTOE）常被视为等同，因为这两个参数均通过近红外光谱法（NIRS）测量，且用于评估组织中的氧摄取情况。本研究旨在探讨这两个参数的可比性及其在检测微循环障碍方面的潜力。
方法
纳入接受了上肢（UE）和下肢（LE）NIRS测量的足月儿和早产儿。pFOE通过NIRS和静脉阻塞法测量的外周肌肉混合静脉血氧饱和度（pSvO）以及动脉血氧饱和度（SpO）计算得出。pFTOE通过外周肌肉组织血氧饱和度和SpO计算得出。使用Wilcoxon符号秩检验和Bland-Altman图对这两个参数进行比较。
结果
共纳入341次NIRS测量。在两个部位，pFOE均显著高于pFTOE。Bland-Altman图显示两者的可比性有限，尤其是当pFOE值较高时，随着氧摄取增加，pFOE与pFTOE的差异更为明显。
结论
与pFTOE相比，pFOE更高，这表明pFOE在检测微循环障碍方面具有更高的潜力，尤其是在氧摄取升高时。
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