Chang Hui-Ping, Huang Meng-Chuan, Lei Yen-Ping, Chuang Yu-Ju, Wang Chun-Wei, Sheen Lee-Yan
Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan.
Department of Dietetics and Nutrition, Taipei City Hospital, Taipei, Taiwan.
J Tradit Complement Med. 2022 Mar 25;12(5):488-498. doi: 10.1016/j.jtcme.2022.03.004. eCollection 2022 Sep.
Concurrent chemoradiotherapy (CCRT)-induced oral mucositis (OM) causes oral pain, malnutrition, and impaired quality of life in patients with head and neck cancer (HNC). Phytochemicals play a potential role in eliminating cancer therapy toxicity.
To evaluate the effect of phytochemical-rich vegetable and fruit juice (VFJ) consumption in preventing CCRT-induced OM among patients with locally advanced HNC.
Forty-nine patients with HNC undergoing CCRT were enrolled. All patients received nutritional counseling before CCRT and weekly follow-up. The VFJ group (25 patients) received 600 mL/day VFJ, 5 days/week for two weeks preceding CCRT and during CCRT, and the control group (24 patients) did not. The contents of total polyphenols and carotenoids in the VFJ were determined. Changes in anthropometric, dietary, and laboratory profiles were compared. Assessment of OM was based on the World Health Organization (WHO) scoring system.
Total polyphenols content was 64.6 mg gallic acid equivalents per 100 mL of the VFJ, and the main carotenoids were β-carotene and lycopene. The mean daily consumption of the VFJ was 538 mL for VFJ group. Changes in body weight, albumin, and energy intake were not significantly different between the two groups. The incidence of ulcerative OM was significantly lower in VFJ (64.0%) than in control (95.8%) subjects at week 6 of CCRT. Multiple logistic regressions revealed that VFJ consumption correlated significantly with lower risks of ulcerative OM.
Consumption of VFJ rich in phytochemicals including total polyphenols and carotenoids effectively alleviates the severity of CCRT-induced OM among patients with locally advanced HNC.
Preventive Medicine; Dietary Therapy/Nutrition Supplements.
(classification by EVISE)Preventive medicine, dietary therapy, nutrition supplements.
同步放化疗（CCRT）诱发的口腔黏膜炎（OM）会导致头颈部癌（HNC）患者出现口腔疼痛、营养不良及生活质量受损。植物化学物质在消除癌症治疗毒性方面具有潜在作用。
评估饮用富含植物化学物质的蔬菜和水果汁（VFJ）对预防局部晚期HNC患者CCRT诱发的OM的效果。
纳入49例接受CCRT的HNC患者。所有患者在CCRT前接受营养咨询并每周随访。VFJ组（25例患者）在CCRT前两周及CCRT期间每周5天、每天饮用600 mL VFJ，对照组（24例患者）则不饮用。测定VFJ中总多酚和类胡萝卜素的含量。比较人体测量、饮食和实验室指标的变化。基于世界卫生组织（WHO）评分系统对OM进行评估。
VFJ中总多酚含量为每100 mL含64.6 mg没食子酸当量，主要类胡萝卜素为β-胡萝卜素和番茄红素。VFJ组VFJ的日均摄入量为538 mL。两组间体重、白蛋白和能量摄入的变化无显著差异。在CCRT第6周时，VFJ组溃疡性OM的发生率（64.0%）显著低于对照组（95.8%）。多因素logistic回归显示，饮用VFJ与溃疡性OM风险降低显著相关。
饮用富含包括总多酚和类胡萝卜素在内的植物化学物质的VFJ可有效减轻局部晚期HNC患者CCRT诱发的OM的严重程度。
预防医学；饮食疗法/营养补充剂。
（按EVISE分类）预防医学、饮食疗法、营养补充剂。
