El-Ani A S, Pickren J W, Fitzpatrick J E
Am J Clin Pathol. 1978 Sep;70(3):423-8. doi: 10.1093/ajcp/70.3.423.
In a Caucasian woman who had had a giant follicular lymphoma for 21 months a small lesion developed in the upper lobe of the left lung. Excision, histologic study, and culture of the lesion were performed. Of the many stained sections, only one revealed endospore-containing spherules within the caseous necrosis of a granuloma, and only four spherules were identified. On agar medium the same tissue yielded a fast-growing fungus that produced arthrospores alternating with empty cells, typical of Coccidioides immitis. The arthrospore suspension was inoculated intraperitoneally into a mouse and into a medium of human pleural fluid at 40 C. Spherules containing endospores developed in the internal organs of the mouse and in the pleural fluid medium. The phylogeny of C. immitis is briefly discussed.
一名患有巨大滤泡性淋巴瘤21个月的白种女性，左肺上叶出现一个小病灶。对该病灶进行了切除、组织学研究和培养。在众多染色切片中，只有一张在肉芽肿的干酪样坏死内显示出含内生孢子的小球体，且仅鉴定出4个小球体。在琼脂培养基上，同一组织培养出一种生长迅速的真菌，产生的关节孢子与空细胞交替出现，这是粗球孢子菌的典型特征。将关节孢子悬液经腹腔接种到一只小鼠体内，并接种到40℃的人胸水培养基中。含内生孢子的小球体在小鼠的内脏器官和胸水培养基中形成。本文简要讨论了粗球孢子菌的系统发育。
