特发性血小板减少性紫癜中的血小板相关免疫球蛋白和补体
Platelet associated immunoglobulins and complement in idiopathic thrombocytopenic purpura.
作者信息
Winiarski J, Holm G
出版信息
Clin Exp Immunol. 1983 Jul;53(1):201-7.
A double antibody sandwich enzyme linked immunosorbent assay (ELISA) was applied to quantitate platelet associated (PA) immunoglobulins G, A and M and complement factors C3c and C4. Fifteen patients with acute and 29 patients with chronic idiopathic thrombocytopenic purpura (ITP) were studied as well as 35 normal controls. Forty-three out of 44 (98%) patients had elevated platelet associated immunoglobulins. PAIgG was elevated in 95%, PAIgA in 82% and PAIgM in 74% of the patients. PAC3 was increased in 86% and PAC4 in 57% of the patients. There was strong correlation between PAC3 and PAIgG but not between PAC4 and PAIgG in acute ITP. In chronic ITP, however, PAC4 correlated strongly and even better than PAC3 with PAIgG. This strengthens the conjecture that the pathogenesis of ITP in many acute cases differs from that of chronic ITP.
采用双抗体夹心酶联免疫吸附测定法（ELISA）对血小板相关（PA）免疫球蛋白G、A和M以及补体因子C3c和C4进行定量分析。研究了15例急性特发性血小板减少性紫癜（ITP）患者和29例慢性ITP患者，以及35名正常对照者。44例患者中有43例（98%）血小板相关免疫球蛋白升高。95%的患者PAIgG升高，82%的患者PAIgA升高，74%的患者PAIgM升高。86%的患者PAC3升高，57%的患者PAC4升高。在急性ITP中，PAC3与PAIgG之间存在强相关性，但PAC4与PAIgG之间无相关性。然而，在慢性ITP中，PAC4与PAIgG的相关性很强，甚至比PAC3与PAIgG的相关性更好。这强化了这样一种推测，即许多急性ITP病例的发病机制与慢性ITP不同。
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