• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

人类精氨酸酶1，是个多面手？

Human arginase 1, a Jack of all trades?

作者信息

Anakha J, Kawathe Priyanka S, Datta Sayantap, Jawalekar Snehal Sainath, Banerjee Uttam Chand, Pande Abhay H

机构信息

Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Mohali, Punjab 160062 India.

Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 4800 Calhoun Rd, Houston, TX 77004 USA.

出版信息

3 Biotech. 2022 Oct;12(10):264. doi: 10.1007/s13205-022-03326-9. Epub 2022 Sep 7.

DOI:10.1007/s13205-022-03326-9
PMID:36082360
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9450830/
Abstract

Arginine, a conditionally essential amino acid, plays a crucial role in several metabolic and signalling pathways. Arginine metabolism in the body can be significantly increased under stress or during certain pathological conditions. Depletion of circulating arginine by administering arginine-hydrolysing enzyme has been shown to mitigate varied pathophysiological conditions ranging from cancer, inflammatory conditions, and microbial infection. This review provides an overview of such intriguing expanse of potential applications of recombinant human arginase 1 for different pathological conditions and its status of development.

摘要

精氨酸是一种条件必需氨基酸，在多种代谢和信号通路中发挥着关键作用。在应激状态下或某些病理状况期间，体内的精氨酸代谢可显著增加。已表明，通过施用精氨酸水解酶消耗循环中的精氨酸可减轻从癌症、炎症性疾病到微生物感染等各种病理生理状况。本综述概述了重组人精氨酸酶1在不同病理状况下如此引人入胜的潜在应用范围及其发展现状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a3/9452612/3465d93164f7/13205_2022_3326_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a3/9452612/bc2317ee4f39/13205_2022_3326_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a3/9452612/86115a0dd370/13205_2022_3326_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a3/9452612/bf7b06d858b2/13205_2022_3326_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a3/9452612/80270b8f55bf/13205_2022_3326_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a3/9452612/3465d93164f7/13205_2022_3326_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a3/9452612/bc2317ee4f39/13205_2022_3326_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a3/9452612/86115a0dd370/13205_2022_3326_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a3/9452612/bf7b06d858b2/13205_2022_3326_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a3/9452612/80270b8f55bf/13205_2022_3326_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a3/9452612/3465d93164f7/13205_2022_3326_Fig5_HTML.jpg

相似文献

1
Human arginase 1, a Jack of all trades?人类精氨酸酶1，是个多面手？
3 Biotech. 2022 Oct;12(10):264. doi: 10.1007/s13205-022-03326-9. Epub 2022 Sep 7.
2
Human arginase I: a potential broad-spectrum anti-cancer agent.人精氨酸酶I：一种潜在的广谱抗癌剂。
3 Biotech. 2023 May;13(5):159. doi: 10.1007/s13205-023-03590-3. Epub 2023 May 3.
3
Development and characterization of fused human arginase I for cancer therapy.融合人精氨酸酶 I 的构建及其在癌症治疗中的特性研究。
Invest New Drugs. 2023 Oct;41(5):652-663. doi: 10.1007/s10637-023-01387-y. Epub 2023 Aug 3.
4
Candida albicans Chitin Increases Arginase-1 Activity in Human Macrophages, with an Impact on Macrophage Antimicrobial Functions.白色念珠菌几丁质增加人巨噬细胞中的精氨酸酶-1活性，对巨噬细胞抗菌功能产生影响。
mBio. 2017 Jan 24;8(1):e01820-16. doi: 10.1128/mBio.01820-16.
5
Remission of hepatocellular carcinoma with arginine depletion induced by systemic release of endogenous hepatic arginase due to transhepatic arterial embolisation, augmented by high-dose insulin: arginase as a potential drug candidate for hepatocellular carcinoma.经肝动脉栓塞术引发内源性肝精氨酸酶全身性释放导致精氨酸耗竭，联合大剂量胰岛素增强作用后，肝细胞癌得以缓解：精氨酸酶作为肝细胞癌潜在的候选药物。
Cancer Lett. 2005 Jun 16;224(1):67-80. doi: 10.1016/j.canlet.2004.10.050. Epub 2004 Dec 25.
6
Arginine deprivation as a strategy for cancer therapy: An insight into drug design and drug combination.精氨酸剥夺作为癌症治疗的一种策略：对药物设计和药物联合的深入了解。
Cancer Lett. 2021 Apr 1;502:58-70. doi: 10.1016/j.canlet.2020.12.041. Epub 2021 Jan 8.
7
Overexpression of arginase alters circulating and tissue amino acids and guanidino compounds and affects neuromotor behavior in mice.精氨酸酶的过表达会改变循环和组织中的氨基酸及胍类化合物，并影响小鼠的神经运动行为。
J Nutr. 2001 Oct;131(10):2732-40. doi: 10.1093/jn/131.10.2732.
8
The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated-recombinant arginase I BCT-100.聚乙二醇化重组精氨酸酶 I BCT-100 可靶向急性淋巴细胞白血病的精氨酸代谢组。
Int J Cancer. 2018 Apr 1;142(7):1490-1502. doi: 10.1002/ijc.31170. Epub 2017 Dec 26.
9
Studies on the advent of ureotelism. Factors that render the hepatic arginase of the Mexican axolotl able to hydrolyse endogenous arginine.关于尿素排泄起源的研究。使墨西哥钝口螈肝脏精氨酸酶能够水解内源性精氨酸的因素。
Biochem J. 1968 Dec;110(3):425-33. doi: 10.1042/bj1100425.
10
Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells.人重组精氨酸酶I（Co）-聚乙二醇5000 [HuArgI（Co）-PEG5000]诱导的精氨酸耗竭对人胶质母细胞瘤细胞具有选择性细胞毒性。
J Neurooncol. 2015 Mar;122(1):75-85. doi: 10.1007/s11060-014-1698-5. Epub 2015 Jan 8.

引用本文的文献

1
Single-variant genome-wide association study and regional heritability mapping of protein efficiency and performance traits in Large White pigs.大白猪蛋白质效率和生产性能性状的单变异全基因组关联研究及区域遗传力定位
Genet Sel Evol. 2025 Aug 14;57(1):45. doi: 10.1186/s12711-025-00993-z.
2
The therapeutic potential of pegylated arginase I treatment in glioblastoma.聚乙二醇化精氨酸酶I治疗胶质母细胞瘤的治疗潜力。
Sci Rep. 2025 Aug 8;15(1):28994. doi: 10.1038/s41598-025-13882-8.
3
Alterations in the cecal microbiome of New Zealand White rabbits due to the long-acting anticoagulant rodenticide brodifacoum.

本文引用的文献

1
Arginine-dependent immune responses.精氨酸依赖的免疫应答。
Cell Mol Life Sci. 2021 Jul;78(13):5303-5324. doi: 10.1007/s00018-021-03828-4. Epub 2021 May 26.
2
Amino Acid Degrading Enzymes and Autophagy in Cancer Therapy.癌症治疗中的氨基酸降解酶与自噬
Front Pharmacol. 2021 Jan 11;11:582587. doi: 10.3389/fphar.2020.582587. eCollection 2020.
3
Clinical effect and safety profile of pegzilarginase in patients with arginase 1 deficiency.精氨酸酶 1 缺乏症患者使用 pegzilarginase 的临床疗效和安全性特征。
长效抗凝血杀鼠剂溴敌隆对新西兰白兔盲肠微生物群的影响
Toxicol Commun. 2025;9(1). doi: 10.1080/24734306.2025.2500111. Epub 2025 May 12.
4
Differential expression of cardiometabolic and inflammation markers and signaling pathways between overweight/obese Qatari adults with high and low plasma salivary α-amylase activity.超重/肥胖卡塔尔成年人中，高和低血浆唾液α-淀粉酶活性与心血管代谢和炎症标志物及信号通路的差异表达。
Front Endocrinol (Lausanne). 2024 Oct 1;15:1421358. doi: 10.3389/fendo.2024.1421358. eCollection 2024.
5
Broad-spectrum anti-cancer activity of fused human arginase variants.融合型人精氨酸酶变体的广谱抗癌活性。
Invest New Drugs. 2024 Oct;42(5):531-537. doi: 10.1007/s10637-024-01466-8. Epub 2024 Aug 20.
6
Recombinant human endostatin as a potential anti-angiogenic agent: therapeutic perspective and current status.重组人血管内皮抑制素作为一种潜在的抗血管生成药物：治疗前景和现状。
Med Oncol. 2023 Dec 21;41(1):24. doi: 10.1007/s12032-023-02245-w.
7
CX3CR1 regulates the development of renal interstitial fibrosis through macrophage polarization.CX3CR1 通过调节巨噬细胞极化影响肾间质纤维化的发生发展。
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023 Jul 28;48(7):957-966. doi: 10.11817/j.issn.1672-7347.2023.220601.
8
Human arginase I: a potential broad-spectrum anti-cancer agent.人精氨酸酶I：一种潜在的广谱抗癌剂。
3 Biotech. 2023 May;13(5):159. doi: 10.1007/s13205-023-03590-3. Epub 2023 May 3.
J Inherit Metab Dis. 2021 Jul;44(4):847-856. doi: 10.1002/jimd.12343. Epub 2021 Jan 26.
4
Arginine depletion as a therapeutic approach for patients with COVID-19.精氨酸耗竭作为 COVID-19 患者的一种治疗方法。
Int J Infect Dis. 2021 Jan;102:566-570. doi: 10.1016/j.ijid.2020.10.100. Epub 2020 Nov 4.
5
Rational design, engineer, and characterization of a novel pegylated single isomer human arginase for arginine depriving anti-cancer treatment.新型聚乙二醇化单一对映异构体人精氨酸酶的合理设计、工程改造及鉴定用于精氨酸剥夺抗癌治疗。
Life Sci. 2021 Jan 1;264:118674. doi: 10.1016/j.lfs.2020.118674. Epub 2020 Oct 28.
6
Arginase as a Potential Biomarker of Disease Progression: A Molecular Imaging Perspective.精氨酸酶作为疾病进展的潜在生物标志物：分子影像学视角。
Int J Mol Sci. 2020 Jul 25;21(15):5291. doi: 10.3390/ijms21155291.
7
A virus that has gone viral: amino acid mutation in S protein of Indian isolate of Coronavirus COVID-19 might impact receptor binding, and thus, infectivity.一种引发病毒传播的病毒：冠状病毒 COVID-19 印度分离株 S 蛋白的氨基酸突变可能影响受体结合，从而影响其传染性。
Biosci Rep. 2020 May 29;40(5). doi: 10.1042/BSR20201312.
8
Pathological findings of COVID-19 associated with acute respiratory distress syndrome.与急性呼吸窘迫综合征相关的新型冠状病毒肺炎的病理表现
Lancet Respir Med. 2020 Apr;8(4):420-422. doi: 10.1016/S2213-2600(20)30076-X. Epub 2020 Feb 18.
9
Protein Chimerization: A New Frontier for Engineering Protein Therapeutics with Improved Pharmacokinetics.蛋白质嵌合体：改善药代动力学的工程蛋白治疗学的新前沿。
J Pharmacol Exp Ther. 2019 Sep;370(3):703-714. doi: 10.1124/jpet.119.257063. Epub 2019 Apr 22.
10
Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses.精氨酸酶 1 通过抑制巨噬细胞炎症反应促进缺血性视网膜神经血管保护。
Cell Death Dis. 2018 Sep 25;9(10):1001. doi: 10.1038/s41419-018-1051-6.