Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Mohali, Punjab, India.
Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Mohali, Punjab, India
J Pharmacol Exp Ther. 2019 Sep;370(3):703-714. doi: 10.1124/jpet.119.257063. Epub 2019 Apr 22.
With the advancement of medicine, the utility of protein therapeutics is increasing exponentially. However, a significant number of protein therapeutics suffer from grave limitations, which include their subpar pharmacokinetics. In this study, we have reviewed the emerging field of protein chimerization for improving the short circulatory half-life of protein therapeutics. We have discussed various aspects of protein therapeutics aiming at their mechanism of clearance and various approaches used to increase their short circulatory half-life with principal focus on the concept of chimerization. Furthermore, we have comprehensively reviewed various components of chimera, such as half-life extension partners and linkers, their shortcomings, and prospective work to be undertaken for developing effective chimeric protein therapeutics.
随着医学的进步，蛋白质疗法的实用性呈指数级增长。然而，相当数量的蛋白质疗法存在严重的局限性，包括它们较差的药代动力学。在这项研究中，我们回顾了蛋白质嵌合化这一新兴领域，以改善蛋白质疗法的短循环半衰期。我们讨论了蛋白质疗法的各个方面，旨在了解其清除机制和各种用于增加短循环半衰期的方法，主要关注嵌合化的概念。此外，我们还全面回顾了嵌合体的各个组成部分，如半衰期延长伴侣和连接子，它们的缺点，以及为开发有效的嵌合蛋白疗法而需要进行的前瞻性工作。
