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Single-cell RNA landscape of cell fate decision of renal proximal tubular epithelial cells and immune-microenvironment in kidney fibrosis.

作者信息

Zhu Minyan, Zhang Zhenhua, Chen Zhejun, Xu Yao, Wu Jiajin, Che Xiajing, Ying Liang, Shao Xinghua, Tang Lumin, Zhou Wenyan, Zhang Minfang, Zhang Ming, Mou Shan

机构信息

Department of Nephrology, Molecular Cell Lab for Kidney Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China.

出版信息

Clin Transl Med. 2022 Sep;12(9):e1010. doi: 10.1002/ctm2.1010.

DOI:10.1002/ctm2.1010
PMID:36082701
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9460484/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84bd/9460484/9c3473470dc1/CTM2-12-e1010-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84bd/9460484/73cd933c7acf/CTM2-12-e1010-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84bd/9460484/721f1098347a/CTM2-12-e1010-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84bd/9460484/7f50c43ef55f/CTM2-12-e1010-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84bd/9460484/9c3473470dc1/CTM2-12-e1010-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84bd/9460484/73cd933c7acf/CTM2-12-e1010-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84bd/9460484/721f1098347a/CTM2-12-e1010-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84bd/9460484/7f50c43ef55f/CTM2-12-e1010-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84bd/9460484/9c3473470dc1/CTM2-12-e1010-g004.jpg

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Proc Natl Acad Sci U S A. 2021 Jun 8;118(23). doi: 10.1073/pnas.2024414118.
2
Farnesoid X receptor promotes renal ischaemia-reperfusion injury by inducing tubular epithelial cell apoptosis.法尼醇 X 受体通过诱导肾小管上皮细胞凋亡促进肾缺血再灌注损伤。
Cell Prolif. 2021 Apr;54(4):e13005. doi: 10.1111/cpr.13005. Epub 2021 Feb 16.
3
The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation.
核受体 ESRRA 通过代谢和分化耦联保护肾脏疾病。
Cell Metab. 2021 Feb 2;33(2):379-394.e8. doi: 10.1016/j.cmet.2020.11.011. Epub 2020 Dec 9.
4
Single-Cell Profiling of AKI in a Murine Model Reveals Novel Transcriptional Signatures, Profibrotic Phenotype, and Epithelial-to-Stromal Crosstalk.单细胞分析揭示了一种新的 AKI 转录特征、成纤维表型和上皮-间质细胞串扰。
J Am Soc Nephrol. 2020 Dec;31(12):2793-2814. doi: 10.1681/ASN.2020010052. Epub 2020 Oct 28.
5
Metabolic pathways and immunometabolism in rare kidney diseases.罕见肾脏疾病中的代谢途径和免疫代谢
Ann Rheum Dis. 2018 Aug;77(8):1226-1233. doi: 10.1136/annrheumdis-2017-212935. Epub 2018 May 3.
6
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Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD.急性肾损伤后导致肾脏加速衰老和慢性肾脏病的适应性修复不良机制。
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